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Database: UniProt
Entry: DNAA_ACHLI
LinkDB: DNAA_ACHLI
Original site: DNAA_ACHLI 
ID   DNAA_ACHLI              Reviewed;         452 AA.
AC   A9NE65;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   07-JUN-2017, entry version 66.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=ACL_0001;
OS   Acholeplasma laidlawii (strain PG-8A).
OC   Bacteria; Tenericutes; Mollicutes; Acholeplasmatales;
OC   Acholeplasmataceae; Acholeplasma.
OX   NCBI_TaxID=441768;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PG-8A;
RX   PubMed=21784942; DOI=10.1128/JB.05059-11;
RA   Lazarev V.N., Levitskii S.A., Basovskii Y.I., Chukin M.M.,
RA   Akopian T.A., Vereshchagin V.V., Kostrjukova E.S., Kovaleva G.Y.,
RA   Kazanov M.D., Malko D.B., Vitreschak A.G., Sernova N.V., Gelfand M.S.,
RA   Demina I.A., Serebryakova M.V., Galyamina M.A., Vtyurin N.N.,
RA   Rogov S.I., Alexeev D.G., Ladygina V.G., Govorun V.M.;
RT   "Complete genome and proteome of Acholeplasma laidlawii.";
RL   J. Bacteriol. 193:4943-4953(2011).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
DR   EMBL; CP000896; ABX80645.1; -; Genomic_DNA.
DR   RefSeq; WP_012241976.1; NC_010163.1.
DR   ProteinModelPortal; A9NE65; -.
DR   SMR; A9NE65; -.
DR   STRING; 441768.ACL_0001; -.
DR   EnsemblBacteria; ABX80645; ABX80645; ACL_0001.
DR   KEGG; acl:ACL_0001; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235658; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000008558; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    452       Chromosomal replication initiator protein
FT                                DnaA.
FT                                /FTId=PRO_1000079939.
FT   NP_BIND     144    151       ATP. {ECO:0000255|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   452 AA;  51805 MW;  67700596BC415A4E CRC64;
     MSPNSTLWQT ILQDLEKLYN EETYNELFLP VTSTFKDQNG LLTMVVANEF LKNRINKLYI
     AKINELATKY SSTPVRLKFV SQEEVIEEPV ADRKLTIDYR QGNLNSTYTF DSFVVGKSNM
     FAFRMAMKVA DQPGAVANPF YIFGDVGLGK THLMQAIGNY ILDNDVEKRI LYVKADNFIE
     DFVSLLSRNK NKTEEFNAKY KDIDVILVDD IQIMANASKT QMEFFKLFDY LYLNNKQIVI
     TSDKPASQLT NIMPRLTTRF EAGLSVDIQI PELEHRISIL KRKTATLDAN LEVSEDILTF
     IASQFAANIR EMEGALIRLI SYAQTFNLEI TMNVVEEALG AVLKTKKKTN DLNENNYDKI
     QSIVADYFQV SLPDLIGKKR HAKFTLPRHI AMYLIKLKYN IPYKTIGSLF NDRDHSTVLS
     ACEKVERDMR MDSNLKFAVD SIVKKIDSPL LK
//
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