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Database: UniProt
Entry: DNAA_ALKMQ
LinkDB: DNAA_ALKMQ
Original site: DNAA_ALKMQ 
ID   DNAA_ALKMQ              Reviewed;         448 AA.
AC   A6TJ76;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-OCT-2017, entry version 61.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=Amet_0001;
OS   Alkaliphilus metalliredigens (strain QYMF).
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae;
OC   Alkaliphilus.
OX   NCBI_TaxID=293826;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=QYMF;
RX   PubMed=27811105; DOI=10.1128/genomeA.01226-16;
RA   Hwang C., Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina Del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Schmutz J.,
RA   Larimer F., Land M.L., Hauser L., Kyrpides N., Mikhailova N., Ye Q.,
RA   Zhou J., Richardson P., Fields M.W.;
RT   "Complete genome sequence of Alkaliphilus metalliredigens strain QYMF,
RT   an alkaliphilic and metal-reducing bacterium isolated from borax-
RT   contaminated leachate ponds.";
RL   Genome Announc. 4:0-0(2016).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
DR   EMBL; CP000724; ABR46244.1; -; Genomic_DNA.
DR   RefSeq; WP_011971153.1; NC_009633.1.
DR   ProteinModelPortal; A6TJ76; -.
DR   SMR; A6TJ76; -.
DR   STRING; 293826.Amet_0001; -.
DR   EnsemblBacteria; ABR46244; ABR46244; Amet_0001.
DR   KEGG; amt:Amet_0001; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235658; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000001572; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    448       Chromosomal replication initiator protein
FT                                DnaA.
FT                                /FTId=PRO_1000060006.
FT   NP_BIND     152    159       ATP. {ECO:0000255|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   448 AA;  50733 MW;  D67B2E9EEC4550C9 CRC64;
     MHDNLPQIWE KAINLIKTEL TEVSFNTWVK PIQAISLDNE TLVLGVPNDF TQGILNARYN
     TLISNAVKQV TSKNYEVHIV VPSEERVGDT QNINARRSNA QSPIMGNSPL ILNPKYTFDT
     FVIGNSNRFA HAASVAVAES PAKAYNPLFI YGGVGLGKTH LMNAIGHYIL ANNPKAKVVY
     VSSETFTNEL INSIRDDRNV EFRNRYRNVD VLLVDDIQFI AGKERTQEEF FHTFNALHES
     NKQIIISSDR PPKEIPTLEE RLRSRFEWGL ITDIQPPDLE TRIAILRKKA QMENIYVPDE
     VTAHIAKKIQ SNIRELEGAL IRIVAYSSLT NSEVTVELAS EALKEIFTSK PRLLNVPLIK
     EVVSNHFSIK LEDFDSKKRT RSISYPRQVA MYLTRELTDL SLPKIGDEFG GRDHTTVMHA
     HSKIVNEINS DSDLKNKLDA IIKELKSD
//
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