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Database: UniProt
Entry: DNAA_AQUAE
LinkDB: DNAA_AQUAE
Original site: DNAA_AQUAE 
ID   DNAA_AQUAE              Reviewed;         399 AA.
AC   O66659;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   07-JUN-2017, entry version 119.
DE   RecName: Full=Chromosomal replication initiator protein DnaA;
GN   Name=dnaA; OrderedLocusNames=aq_322;
OS   Aquifex aeolicus (strain VF5).
OC   Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex.
OX   NCBI_TaxID=224324;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VF5;
RX   PubMed=9537320; DOI=10.1038/32831;
RA   Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L.,
RA   Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R.,
RA   Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.;
RT   "The complete genome of the hyperthermophilic bacterium Aquifex
RT   aeolicus.";
RL   Nature 392:353-358(1998).
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 76-399.
RX   PubMed=12234917; DOI=10.1093/emboj/cdf496;
RA   Erzberger J.P., Pirruccello M.M., Berger J.M.;
RT   "The structure of bacterial DnaA: implications for general mechanisms
RT   underlying DNA replication initiation.";
RL   EMBO J. 21:4763-4773(2002).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000305}.
DR   EMBL; AE000657; AAC06612.1; -; Genomic_DNA.
DR   PIR; G70328; G70328.
DR   RefSeq; NP_213219.1; NC_000918.1.
DR   RefSeq; WP_010880157.1; NC_000918.1.
DR   PDB; 1L8Q; X-ray; 2.70 A; A=76-399.
DR   PDB; 2HCB; X-ray; 3.51 A; A/B/C/D=77-399.
DR   PDB; 3R8F; X-ray; 3.37 A; A/B/C/D=76-399.
DR   PDBsum; 1L8Q; -.
DR   PDBsum; 2HCB; -.
DR   PDBsum; 3R8F; -.
DR   ProteinModelPortal; O66659; -.
DR   SMR; O66659; -.
DR   DIP; DIP-29219N; -.
DR   STRING; 224324.aq_322; -.
DR   EnsemblBacteria; AAC06612; AAC06612; aq_322.
DR   GeneID; 1192893; -.
DR   KEGG; aae:aq_322; -.
DR   PATRIC; fig|224324.8.peg.259; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235658; -.
DR   InParanoid; O66659; -.
DR   KO; K02313; -.
DR   OMA; DFRYLQG; -.
DR   OrthoDB; POG091H02FF; -.
DR   EvolutionaryTrace; O66659; -.
DR   Proteomes; UP000000798; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IBA:GO_Central.
DR   GO; GO:0006270; P:DNA replication initiation; IBA:GO_Central.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   1: Evidence at protein level;
KW   3D-structure; ATP-binding; Complete proteome; Cytoplasm;
KW   DNA replication; DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    399       Chromosomal replication initiator protein
FT                                DnaA.
FT                                /FTId=PRO_0000114122.
FT   NP_BIND     119    126       ATP. {ECO:0000255}.
FT   STRAND       85     87       {ECO:0000244|PDB:1L8Q}.
FT   TURN         92     94       {ECO:0000244|PDB:1L8Q}.
FT   HELIX        95    106       {ECO:0000244|PDB:1L8Q}.
FT   TURN        107    110       {ECO:0000244|PDB:1L8Q}.
FT   STRAND      113    118       {ECO:0000244|PDB:1L8Q}.
FT   STRAND      120    124       {ECO:0000244|PDB:1L8Q}.
FT   HELIX       125    138       {ECO:0000244|PDB:1L8Q}.
FT   STRAND      143    147       {ECO:0000244|PDB:1L8Q}.
FT   HELIX       148    161       {ECO:0000244|PDB:1L8Q}.
FT   HELIX       164    172       {ECO:0000244|PDB:1L8Q}.
FT   STRAND      175    180       {ECO:0000244|PDB:1L8Q}.
FT   HELIX       182    185       {ECO:0000244|PDB:1L8Q}.
FT   HELIX       189    204       {ECO:0000244|PDB:1L8Q}.
FT   STRAND      208    215       {ECO:0000244|PDB:1L8Q}.
FT   HELIX       217    219       {ECO:0000244|PDB:1L8Q}.
FT   HELIX       225    232       {ECO:0000244|PDB:1L8Q}.
FT   STRAND      234    238       {ECO:0000244|PDB:1L8Q}.
FT   HELIX       243    256       {ECO:0000244|PDB:1L8Q}.
FT   HELIX       263    272       {ECO:0000244|PDB:1L8Q}.
FT   HELIX       276    289       {ECO:0000244|PDB:1L8Q}.
FT   HELIX       291    316       {ECO:0000244|PDB:1L8Q}.
FT   HELIX       320    323       {ECO:0000244|PDB:1L8Q}.
FT   STRAND      330    332       {ECO:0000244|PDB:1L8Q}.
FT   HELIX       333    347       {ECO:0000244|PDB:1L8Q}.
FT   HELIX       351    357       {ECO:0000244|PDB:1L8Q}.
FT   HELIX       365    375       {ECO:0000244|PDB:1L8Q}.
FT   HELIX       383    398       {ECO:0000244|PDB:1L8Q}.
SQ   SEQUENCE   399 AA;  46840 MW;  C641CB199AA79906 CRC64;
     MELNALIKKI ESVDSYAREF LKKFEIKQEK GKFLFIAPGE DYREWLETIV NTFLEEEVRK
     LIEVKEKEEK KKVEIKDFLN PKYTLENFIV GEGNRLAYEV VKEALENLGS LYNPIFIYGS
     VGTGKTHLLQ AAGNEAKKRG YRVIYSSADD FAQAMVEHLK KGTINEFRNM YKSVDLLLLD
     DVQFLSGKER TQIEFFHIFN TLYLLEKQII LASDRHPQKL DGVSDRLVSR FEGGILVEIE
     LDNKTRFKII KEKLKEFNLE LRKEVIDYLL ENTKNVREIE GKIKLIKLKG FEGLERKERK
     ERDKLMQIVE FVANYYAVKV EDILSDKRNK RTSEARKIAM YLCRKVCSAS LIEIARAFKR
     KDHTTVIHAI RSVEEEKKKD RKFKHLVGFL EKQAFDKIC
//
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