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Database: UniProt
Entry: DNAA_BACHD
LinkDB: DNAA_BACHD
Original site: DNAA_BACHD 
ID   DNAA_BACHD              Reviewed;         449 AA.
AC   Q9RCA2;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-OCT-2017, entry version 104.
DE   RecName: Full=Chromosomal replication initiator protein DnaA;
GN   Name=dnaA; OrderedLocusNames=BH0001;
OS   Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM
OS   9153 / C-125).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=272558;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125;
RX   PubMed=10427704; DOI=10.1271/bbb.63.1134;
RA   Takami H., Masui N., Nakasone K., Horikoshi K.;
RT   "Replication origin region of the chromosome of alkaliphilic Bacillus
RT   halodurans C-125.";
RL   Biosci. Biotechnol. Biochem. 63:1134-1137(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125;
RX   PubMed=11058132; DOI=10.1093/nar/28.21.4317;
RA   Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N.,
RA   Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S.,
RA   Horikoshi K.;
RT   "Complete genome sequence of the alkaliphilic bacterium Bacillus
RT   halodurans and genomic sequence comparison with Bacillus subtilis.";
RL   Nucleic Acids Res. 28:4317-4331(2000).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000305}.
DR   EMBL; AB013492; BAA82685.1; -; Genomic_DNA.
DR   EMBL; BA000004; BAB03720.1; -; Genomic_DNA.
DR   PIR; A83650; A83650.
DR   RefSeq; WP_010896185.1; NC_002570.2.
DR   ProteinModelPortal; Q9RCA2; -.
DR   SMR; Q9RCA2; -.
DR   STRING; 272558.BH0001; -.
DR   EnsemblBacteria; BAB03720; BAB03720; BAB03720.
DR   KEGG; bha:BH0001; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000001258; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    449       Chromosomal replication initiator protein
FT                                DnaA.
FT                                /FTId=PRO_0000114129.
FT   NP_BIND     153    160       ATP. {ECO:0000255}.
SQ   SEQUENCE   449 AA;  51263 MW;  D75C00BBF110A614 CRC64;
     MENIHDLWER ALKSMEKKVS KPSFETWLKQ TKANSIEDST IIITAPNEFA RDWLEKHYDE
     LISETIDDLT GVRLYPKFVI PTSQLDEPFV EQELKKPMKQ PPAQNGEMPN NMLNDKYTFD
     TFVIGSGNRF AHAASLAVAE APAKAYNPLF IYGGVGLGKT HLMHAIGHYV MDHNPNAKVV
     YLSSEKFTNE FINAIRDNKA VNFRNKYRNV DVLLIDDIQF LAGKEQTQEE FFHTFNALHE
     DNKQIVISSD RPPKEIPTLE DRLRSRFEWG LITDITPPDL ETRIAILRKK AKAENLDIPN
     EVMLYIANQI DTNIRELEGA LIRVVAYSSL INQDMNADLA AEALKDIIPN AKPRVLTITD
     IQKTVGEYFH VKLEDFKAKK RTKSVAFPRQ IAMYLSRELT DASLPKIGSE FGGRDHTTVI
     HAHEKISKLL STDQELQDKI QDISDKLRS
//
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