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Database: UniProt
Entry: DNAA_BACTN
LinkDB: DNAA_BACTN
Original site: DNAA_BACTN 
ID   DNAA_BACTN              Reviewed;         470 AA.
AC   Q8A5U5;
DT   07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   07-JUN-2017, entry version 96.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=BT_2143;
OS   Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC
OS   10582 / E50 / VPI-5482).
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=226186;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482;
RX   PubMed=12663928; DOI=10.1126/science.1080029;
RA   Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K.,
RA   Chiang H.C., Hooper L.V., Gordon J.I.;
RT   "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.";
RL   Science 299:2074-2076(2003).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
DR   EMBL; AE015928; AAO77250.1; -; Genomic_DNA.
DR   RefSeq; NP_811056.1; NC_004663.1.
DR   RefSeq; WP_008759760.1; NC_004663.1.
DR   ProteinModelPortal; Q8A5U5; -.
DR   SMR; Q8A5U5; -.
DR   STRING; 226186.BT_2143; -.
DR   PaxDb; Q8A5U5; -.
DR   EnsemblBacteria; AAO77250; AAO77250; BT_2143.
DR   GeneID; 1074333; -.
DR   GeneID; 31615430; -.
DR   KEGG; bth:BT_2143; -.
DR   PATRIC; fig|226186.12.peg.2207; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235658; -.
DR   InParanoid; Q8A5U5; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000001414; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IBA:GO_Central.
DR   GO; GO:0006270; P:DNA replication initiation; IBA:GO_Central.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    470       Chromosomal replication initiator protein
FT                                DnaA.
FT                                /FTId=PRO_0000114134.
FT   NP_BIND     173    180       ATP. {ECO:0000255|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   470 AA;  53251 MW;  870D935B43D60C98 CRC64;
     MIESNHVVLW NRCLEVIKDN VPETTYNTWF APIVPLKYED KTLIVQIPSQ FFYEILEEKF
     VDLLRKTLYK AIGEGTKLMY NVMVDKTSIP NQTVNLEASN RSTAVTPKSI VGGNKAPSFL
     KAPAVQDLDP HLNPNYNFEN FIEGYSNKLS RSVAEAVAQN PAGTAFNPLF LYGASGVGKT
     HLANAIGTKI KELYADKRVL YVSAHLFQVQ YTDSVRNNTT NDFINFYQTI DVLIIDDIQE
     FAGVTKTQNT FFHIFNHLHQ NGKQLILTSD RAPVLLQGME ERLLTRFKWG MVAELEKPTV
     ELRKNILRNK IHRDGLQFPP EVIDYIAENV NESVRDLEGI VIAIMARSTI FNKEIDLDLA
     QHIVHGVVHN ETKAVTIDDI LKVVCKHFDL EASAIHTKSR KREVVQARQI AMYLAKNYTD
     FSTSKIGKFI GNKDHATVLH ACKTVKGQLE VDKSFQAEVQ EIESLLKKKA
//
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