GenomeNet

Database: UniProt
Entry: DNAA_BORBU
LinkDB: DNAA_BORBU
Original site: DNAA_BORBU 
ID   DNAA_BORBU              Reviewed;         486 AA.
AC   P33768;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   07-JUN-2017, entry version 119.
DE   RecName: Full=Chromosomal replication initiator protein DnaA;
GN   Name=dnaA; OrderedLocusNames=BB_0437;
OS   Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM
OS   4680).
OC   Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borreliella.
OX   NCBI_TaxID=224326;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=212;
RX   PubMed=8359672; DOI=10.1111/j.1574-6968.1993.tb06369.x;
RA   Old I.G., Margarita D., Saint-Girons I.;
RT   "Unique genetic arrangement in the dnaA region of the Borrelia
RT   burgdorferi linear chromosome: nucleotide sequence of the dnaA gene.";
RL   FEMS Microbiol. Lett. 111:109-114(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35210 / B31 / CIP 102532 / DSM 4680;
RX   PubMed=9403685; DOI=10.1038/37551;
RA   Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A.,
RA   Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K.,
RA   Gwinn M.L., Dougherty B.A., Tomb J.-F., Fleischmann R.D.,
RA   Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J.,
RA   Salzberg S.L., Hanson M., van Vugt R., Palmer N., Adams M.D.,
RA   Gocayne J.D., Weidman J.F., Utterback T.R., Watthey L., McDonald L.A.,
RA   Artiach P., Bowman C., Garland S.A., Fujii C., Cotton M.D., Horst K.,
RA   Roberts K.M., Hatch B., Smith H.O., Venter J.C.;
RT   "Genomic sequence of a Lyme disease spirochaete, Borrelia
RT   burgdorferi.";
RL   Nature 390:580-586(1997).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000305}.
DR   EMBL; U04527; AAA58941.1; -; Genomic_DNA.
DR   EMBL; AE000783; AAB91515.1; -; Genomic_DNA.
DR   PIR; D70154; D70154.
DR   RefSeq; NP_212571.1; NC_001318.1.
DR   RefSeq; WP_002656657.1; NC_001318.1.
DR   ProteinModelPortal; P33768; -.
DR   SMR; P33768; -.
DR   STRING; 224326.BB_0437; -.
DR   PRIDE; P33768; -.
DR   EnsemblBacteria; AAB91515; AAB91515; BB_0437.
DR   GeneID; 1195282; -.
DR   KEGG; bbu:BB_0437; -.
DR   PATRIC; fig|224326.49.peg.828; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   Proteomes; UP000001807; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    486       Chromosomal replication initiator protein
FT                                DnaA.
FT                                /FTId=PRO_0000114140.
FT   NP_BIND     183    190       ATP. {ECO:0000255}.
SQ   SEQUENCE   486 AA;  56783 MW;  27CA6BE6A9BA39BC CRC64;
     MEKSKNIWSL ILTEIKKELS EEEFYVWFEN LCFLESIGDN IKISTPNLFH KNQIEKRFTK
     KIKEILIKNG YNNIVIVFTN QPPKTHSNKQ ETKNPALNET FSKFDKLKEK TTSKEAIQNI
     QDRIKMYIKK EEEEPTNFKN PFLKKRYTFE NFIIGPNNKL AYNASLSISK NPGKKYNPCL
     IYGGVGLGKT HLLQSIGNKT EELHHNLKIL YVTAENFLNE FVESIKTHET KKFKKKYRYL
     DMLLIDDIHD LQKKEGIQEE LFHTFNALYE DNKQLVFTCD RSPSELTNFT DRLKSRFTRG
     LNVDISKPNF ELRAAIVEKK AEEDGINVPK NILNLVAQKV TTNVRDLEAA VTKLKAYIDL
     DNIEIDIEIV EKIIKEIIIY EKETTNEPNN KINIENIKKI LLRELKITHK DIEGHSKKPE
     ITKARHIYAY LLRNFTELST VEIGKIIGGK THSTVLYSIN KIDRDRNNDK EINNLITELM
     NKIKKN
//
DBGET integrated database retrieval system