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Database: UniProt
Entry: DNAA_CAUSK
LinkDB: DNAA_CAUSK
Original site: DNAA_CAUSK 
ID   DNAA_CAUSK              Reviewed;         487 AA.
AC   B0T135;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   25-OCT-2017, entry version 62.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=Caul_0001;
OS   Caulobacter sp. (strain K31).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter.
OX   NCBI_TaxID=366602;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K31;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T.,
RA   Dalin E., Tice H., Pitluck S., Bruce D., Goodwin L., Thompson L.S.,
RA   Brettin T., Detter J.C., Han C., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Kim E., Stephens C., Richardson P.;
RT   "Complete sequence of chromosome of Caulobacter sp. K31.";
RL   Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
DR   EMBL; CP000927; ABZ69139.1; -; Genomic_DNA.
DR   RefSeq; WP_012284097.1; NC_010338.1.
DR   ProteinModelPortal; B0T135; -.
DR   SMR; B0T135; -.
DR   STRING; 366602.Caul_0001; -.
DR   EnsemblBacteria; ABZ69139; ABZ69139; Caul_0001.
DR   KEGG; cak:Caul_0001; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235660; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000001316; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    487       Chromosomal replication initiator protein
FT                                DnaA.
FT                                /FTId=PRO_1000079941.
FT   NP_BIND     186    193       ATP. {ECO:0000255|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   487 AA;  53790 MW;  75447173A4CDD37C CRC64;
     MTIKGGVVSQ DFSAAFSTVA CEPAGVVWNK VCTVLKRELG DAAFGSWIAP AVLREGPSGD
     VVVVTPTGIA RDWIRRSAWR RVSELWTAND ATGRRLDLKS RLEFESVGGA GYEAKAEPIE
     IVLPVSSDVP ALAPTNGSKP SPVQGLQERF TFDTFVPGPA NEFAHAVARR VASWADGHFN
     PVLFHGPYGF GKTHLLNALA WEAMRQAPTK RVVYLTAERF LSTFVRAVMD RQTAAFKEEL
     RGADLLIIDD VHFIAGKQSS QEELFHTLTA LVEDGRRVVF SSDRAPAAMT EMDARLRSHL
     SAGLVCGLEP ADRALRIGIL ERKLQALSRQ HGFEPTLRAE VLNFLADRFT DSVRELEGAL
     NTLSARAGEG VSRLTLEEVQ AILRPHLRAG EKRITIDDIQ KATSEHYGMK QVDLLSERRN
     RAIARPRQAA MWLAKQLTTR SLPDIGRRFG GRDHTTVLHA VRRIEALRAD DPVLSQDLET
     ITRKLRG
//
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