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Database: UniProt
Entry: DNAA_CLOAB
LinkDB: DNAA_CLOAB
Original site: DNAA_CLOAB 
ID   DNAA_CLOAB              Reviewed;         446 AA.
AC   Q97N35;
DT   07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   25-OCT-2017, entry version 96.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=CA_C0001;
OS   Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG
OS   5710 / VKM B-1787).
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=272562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787;
RX   PubMed=11466286; DOI=10.1128/JB.183.16.4823-4838.2001;
RA   Noelling J., Breton G., Omelchenko M.V., Makarova K.S., Zeng Q.,
RA   Gibson R., Lee H.M., Dubois J., Qiu D., Hitti J., Wolf Y.I.,
RA   Tatusov R.L., Sabathe F., Doucette-Stamm L.A., Soucaille P.,
RA   Daly M.J., Bennett G.N., Koonin E.V., Smith D.R.;
RT   "Genome sequence and comparative analysis of the solvent-producing
RT   bacterium Clostridium acetobutylicum.";
RL   J. Bacteriol. 183:4823-4838(2001).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
DR   EMBL; AE001437; AAK77988.1; -; Genomic_DNA.
DR   PIR; A96900; A96900.
DR   RefSeq; NP_346648.1; NC_003030.1.
DR   RefSeq; WP_010963330.1; NC_003030.1.
DR   ProteinModelPortal; Q97N35; -.
DR   SMR; Q97N35; -.
DR   STRING; 272562.CA_C0001; -.
DR   EnsemblBacteria; AAK77988; AAK77988; CA_C0001.
DR   GeneID; 1116184; -.
DR   KEGG; cac:CA_C0001; -.
DR   PATRIC; fig|272562.8.peg.180; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235658; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   Proteomes; UP000000814; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    446       Chromosomal replication initiator protein
FT                                DnaA.
FT                                /FTId=PRO_0000114165.
FT   NP_BIND     149    156       ATP. {ECO:0000255|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   446 AA;  50869 MW;  BF181A5BDEFF4BDE CRC64;
     MAAQLNELWQ KTINIIKGEL TEVSFNTWIK SITPISIDKD SIRLSVPNQF TKEILENRYK
     DLIINSMKII TTKKYDIAFL ISSEEALETD EDQETDTNNV NTDTSSSMLN PKYKFDSFVI
     GNSNRFAHAA CLAVAEAPAK AYNPLFIYGG VGLGKTHLMQ AIGHYILDNN PKAKVVYVSS
     EKFTNELINS IKDDKNVEFR NKYRNVDVLL IDDVQFIAGK ERTQEEFFHT FNALHENNKQ
     IILSSDRPPK EIPTLEDRLR SRFEWGLIAD IQAPDFETRI AILKKKADVE HLNIPNDVMV
     YIATQIKSNI RELEGALIRI VAFSSLTNKE ISVDLASEAL KDIISSKQNK QITIDLIQDV
     VSSYFNLRIE DFKSARRTKN IAFPRQIAMY LSRKLTDMSL PKIGEAFGGR DHTTVIHAYE
     KISSALKEDD DLKYTINEIT KRFSPK
//
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