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Database: UniProt
Entry: DNAA_CLOBB
LinkDB: DNAA_CLOBB
Original site: DNAA_CLOBB 
ID   DNAA_CLOBB              Reviewed;         456 AA.
AC   B2THB4;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 1.
DT   25-OCT-2017, entry version 67.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=CLL_A0001;
OS   Clostridium botulinum (strain Eklund 17B / Type B).
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=935198;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Eklund 17B / Type B;
RA   Brinkac L.M., Brown J.L., Bruce D., Detter C., Munk C., Smith L.A.,
RA   Smith T.J., Sutton G., Brettin T.S.;
RT   "Complete sequence of Clostridium botulinum strain Eklund.";
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
DR   EMBL; CP001056; ACD25095.1; -; Genomic_DNA.
DR   RefSeq; WP_012425816.1; NC_018648.1.
DR   ProteinModelPortal; B2THB4; -.
DR   SMR; B2THB4; -.
DR   EnsemblBacteria; ACD25095; ACD25095; CLL_A0001.
DR   GeneID; 19966808; -.
DR   KEGG; cbk:CLL_A0001; -.
DR   PATRIC; fig|935198.13.peg.1; -.
DR   HOGENOM; HOG000235658; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   Proteomes; UP000001195; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    456       Chromosomal replication initiator protein
FT                                DnaA.
FT                                /FTId=PRO_1000121962.
FT   NP_BIND     159    166       ATP. {ECO:0000255|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   456 AA;  51990 MW;  FC13C3FA234FF565 CRC64;
     MDADLNKLWE KTLNIVKSEM SEVSFNTWIK SCEPISISDT SIKISVPNSF TKDILDKRYK
     SLVANSIEAV CSKLYEIKFI IESDLNNEDE LNNSDNSDKN RDKNSRRNIV VNDEMSSTLN
     PKYTFNSFVI GNSNRFAHAA SLAVAEAPAK AYNPLFIYGG VGLGKTHLMH AIGHYILQNN
     TKAKVVYVSS EKFTNELINA IKDDKNEEFR KKYRNVDVLL IDDIQFIAGK ERTQEEFFHT
     FNELHDANKQ IILSSDRPPK EIPTLEDRLR SRFEWGLIAD IQVPDFETRM AILKKKADVE
     NLKVANEVMG YIATKIKSNI RELEGALIRI IAYSSLTNRE VTVDLASEAL KDIISKKQGK
     HVTIPSIQEI VANYFNLKID DLKSQRRTRN VAYPRQIAMY LSRKLTDMSL PKIGEEFGGR
     DHTTVIHAYE KISENLKSDE SLQHTVSDIT KKVSQN
//
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