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Database: UniProt
Entry: DNAA_CLOBH
LinkDB: DNAA_CLOBH
Original site: DNAA_CLOBH 
ID   DNAA_CLOBH              Reviewed;         448 AA.
AC   A5HXP7; A7FZS7;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-JUN-2007, sequence version 1.
DT   07-JUN-2017, entry version 65.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=CBO0001, CLC_0001;
OS   Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A).
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=441771;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hall / ATCC 3502 / NCTC 13319 / Type A;
RX   PubMed=17519437; DOI=10.1101/gr.6282807;
RA   Sebaihia M., Peck M.W., Minton N.P., Thomson N.R., Holden M.T.G.,
RA   Mitchell W.J., Carter A.T., Bentley S.D., Mason D.R., Crossman L.,
RA   Paul C.J., Ivens A., Wells-Bennik M.H.J., Davis I.J.,
RA   Cerdeno-Tarraga A.M., Churcher C., Quail M.A., Chillingworth T.,
RA   Feltwell T., Fraser A., Goodhead I., Hance Z., Jagels K., Larke N.,
RA   Maddison M., Moule S., Mungall K., Norbertczak H., Rabbinowitsch E.,
RA   Sanders M., Simmonds M., White B., Whithead S., Parkhill J.;
RT   "Genome sequence of a proteolytic (Group I) Clostridium botulinum
RT   strain Hall A and comparative analysis of the clostridial genomes.";
RL   Genome Res. 17:1082-1092(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hall / ATCC 3502 / NCTC 13319 / Type A;
RX   PubMed=18060065; DOI=10.1371/journal.pone.0001271;
RA   Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C.,
RA   Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S.;
RT   "Analysis of the neurotoxin complex genes in Clostridium botulinum A1-
RT   A4 and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within
RT   plasmids.";
RL   PLoS ONE 2:E1271-E1271(2007).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
DR   EMBL; CP000727; ABS36825.1; -; Genomic_DNA.
DR   EMBL; AM412317; CAL81555.1; -; Genomic_DNA.
DR   RefSeq; WP_011947895.1; NC_009698.1.
DR   RefSeq; YP_001252553.1; NC_009495.1.
DR   RefSeq; YP_001385963.1; NC_009698.1.
DR   ProteinModelPortal; A5HXP7; -.
DR   SMR; A5HXP7; -.
DR   EnsemblBacteria; ABS36825; ABS36825; CLC_0001.
DR   GeneID; 5187220; -.
DR   GeneID; 5400372; -.
DR   KEGG; cbh:CLC_0001; -.
DR   KEGG; cbo:CBO0001; -.
DR   PATRIC; fig|413999.7.peg.1; -.
DR   HOGENOM; HOG000235658; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   PRO; PR:A5HXP7; -.
DR   Proteomes; UP000001986; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IBA:GO_Central.
DR   GO; GO:0006270; P:DNA replication initiation; IBA:GO_Central.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    448       Chromosomal replication initiator protein
FT                                DnaA.
FT                                /FTId=PRO_1000048633.
FT   NP_BIND     151    158       ATP. {ECO:0000255|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   448 AA;  51324 MW;  FE0D09B57811CEFC CRC64;
     MNTHLTETWE KAINIIKGEL TEVSFNTWIK SINPISLENN SLKLAVPNDF TKGILESRYK
     DLIVNALKLL TSKKYNIDFI VTTEEKIEEN QKNHNNEKSN IVVNDEMSTM LNPKYTFDSF
     VIGNSNRFAH AASLAVAESP AKAYNPLFIY GGVGLGKTHL MHAIGHYILH NNPKSQVVYV
     SSEKFTNELI NSIKDDKNVE FRNKYRNIDI LLVDDIQFIA GKERTQEEFF HTFNALYEAN
     KQIIISSDRP PKEIPTLEDR LRSRFEWGLI ADIQAPDFET RMAILKKKAD VENLNIPNEV
     MVYIATKIKS NIRELEGALI RIVAFSSLTN KEISIDLASE ALKDIISSKQ TRQVTIDIIQ
     EVVANYYNLK IEDLKSARRT RNIAFPRQIA MYLSRKLTDM SLPKIGEEFG GRDHTTVIHA
     YEKISNNLKK DESLQNAIKE LNKRINQK
//
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