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Database: UniProt
Entry: DNAA_CLOCE
LinkDB: DNAA_CLOCE
Original site: DNAA_CLOCE 
ID   DNAA_CLOCE              Reviewed;         440 AA.
AC   B8I3R2;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   25-OCT-2017, entry version 53.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=Ccel_0001;
OS   Clostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 /
OS   H10).
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Ruminococcaceae;
OC   Ruminiclostridium.
OX   NCBI_TaxID=394503;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35319 / DSM 5812 / JCM 6584 / H10;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Saunders E.,
RA   Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Ivanova N., Zhou J., Richardson P.;
RT   "Complete sequence of Clostridium cellulolyticum H10.";
RL   Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
DR   EMBL; CP001348; ACL74389.1; -; Genomic_DNA.
DR   RefSeq; WP_012634456.1; NC_011898.1.
DR   ProteinModelPortal; B8I3R2; -.
DR   SMR; B8I3R2; -.
DR   STRING; 394503.Ccel_0001; -.
DR   EnsemblBacteria; ACL74389; ACL74389; Ccel_0001.
DR   KEGG; cce:Ccel_0001; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235658; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000001349; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    440       Chromosomal replication initiator protein
FT                                DnaA.
FT                                /FTId=PRO_1000189790.
FT   NP_BIND     143    150       ATP. {ECO:0000255|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   440 AA;  50088 MW;  5326B4110E58734D CRC64;
     MNVQLNEIWN RTLELLKGEM TEISFNTWIL TIEPISIDSN TITLGVPADF NKGILEARYS
     YLIKNALRQI SHRDYNIYFA IPSQTPVKPV AQEYTEDSNM SFLNPKYTFD TFVIGNGNRF
     AHAASLAVAE APAKAYNPLF LYGGVGLGKT HLMHAIGHFV LSQNPALKVL YVSSEKFTNE
     LINAIRDDKN EEFRYKYRNI DVLLIDDIQF IGGKERTEEE FFHTFNALYE ANKQIIISSD
     KPPKEIPTLE DRLRSRFEWG LIADIAPPDL ETRIAILRKK AQLENLDVPD DVMVFIADKV
     ASNIRELEGA LNRVIAYSTL TENIINVDMA VEALKDMLNN SKAIIINSKT IQEAVARYFH
     LKTDDLKSKR RSRDVSFPRQ IAMYLCRDMT DMSLPKIGDE FGGRDHTTVI HACEKINNDL
     NNSTELKRTV EEIKKNITGG
//
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