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Database: UniProt
Entry: DNAA_CLOK5
LinkDB: DNAA_CLOK5
Original site: DNAA_CLOK5 
ID   DNAA_CLOK5              Reviewed;         451 AA.
AC   A5N457;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   07-JUN-2017, entry version 68.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=CKL_0001;
OS   Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680).
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=431943;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8527 / DSM 555 / NCIMB 10680;
RX   PubMed=18218779; DOI=10.1073/pnas.0711093105;
RA   Seedorf H., Fricke W.F., Veith B., Brueggemann H., Liesegang H.,
RA   Strittmatter A., Miethke M., Buckel W., Hinderberger J., Li F.,
RA   Hagemeier C., Thauer R.K., Gottschalk G.;
RT   "The genome of Clostridium kluyveri, a strict anaerobe with unique
RT   metabolic features.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:2128-2133(2008).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
DR   EMBL; CP000673; EDK32088.1; -; Genomic_DNA.
DR   RefSeq; WP_011988614.1; NC_009706.1.
DR   ProteinModelPortal; A5N457; -.
DR   SMR; A5N457; -.
DR   STRING; 431943.CKL_0001; -.
DR   EnsemblBacteria; EDK32088; EDK32088; CKL_0001.
DR   KEGG; ckl:CKL_0001; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235658; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000002411; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    451       Chromosomal replication initiator protein
FT                                DnaA.
FT                                /FTId=PRO_1000079945.
FT   NP_BIND     154    161       ATP. {ECO:0000255|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   451 AA;  51307 MW;  CDDBA45ACDAEE137 CRC64;
     MNAHPKEIWE QCLNIIKGET TEVSFNTWIK SITPISIEND TFMLTVPNDL TKGILSNKYT
     DLIIRSLQMV TSQKYNVKFL ISSELPEEFL TLDTINEQNI KGSIIVSDEM SAMLNPKYTF
     TSFVIGNSNR FAHAASLAVA ESPAKAYNPL FIYGGVGLGK THLMHAIGHH ILHNNTSCKV
     VYVSSEKFTN ELINSIKDDK NVEFRSKYRN IDVLLIDDIQ FIAGKERTQE EFFHTFNALY
     EANKQIILSS DRPPKEIPTL EDRLRSRFEW GLIADIQPPD FETRMAILKK KADVEKLNIP
     NEVMAYIATK IKSNIRELEG ALIRIVAFSS LTNKEISVDL AIEALKDIIS SGQSKQVTIE
     LIQDVVSNYY NLKVSDFKSS RRTRNVAFPR QIAMYLCRKL TDMSLPKIGE EFGGRDHTTV
     IHAYEKISNN LKKDESLKNA VNDLTKRLDQ Q
//
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