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Database: UniProt
Entry: DNAA_CLONN
LinkDB: DNAA_CLONN
Original site: DNAA_CLONN 
ID   DNAA_CLONN              Reviewed;         448 AA.
AC   A0Q3U6;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 1.
DT   07-JUN-2017, entry version 67.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=NT01CX_0867;
OS   Clostridium novyi (strain NT).
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=386415;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NT;
RX   PubMed=17115055; DOI=10.1038/nbt1256;
RA   Bettegowda C., Huang X., Lin J., Cheong I., Kohli M., Szabo S.A.,
RA   Zhang X., Diaz L.A. Jr., Velculescu V.E., Parmigiani G., Kinzler K.W.,
RA   Vogelstein B., Zhou S.;
RT   "The genome and transcriptomes of the anti-tumor agent Clostridium
RT   novyi-NT.";
RL   Nat. Biotechnol. 24:1573-1580(2006).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
DR   EMBL; CP000382; ABK62135.1; -; Genomic_DNA.
DR   RefSeq; WP_011723269.1; NC_008593.1.
DR   ProteinModelPortal; A0Q3U6; -.
DR   SMR; A0Q3U6; -.
DR   STRING; 386415.NT01CX_0867; -.
DR   EnsemblBacteria; ABK62135; ABK62135; NT01CX_0867.
DR   GeneID; 4541471; -.
DR   KEGG; cno:NT01CX_0867; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235658; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000008220; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    448       Chromosomal replication initiator protein
FT                                DnaA.
FT                                /FTId=PRO_1000048635.
FT   NP_BIND     151    158       ATP. {ECO:0000255|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   448 AA;  51301 MW;  EA9F4266DE4486BB CRC64;
     MNAQLKQLWT KTLNIIKGEL TEVSFNTWIK SISPISMNEN TIKLEVPNDF TRGILESRYK
     DLIINAIKLI TSKKYNIEFS ITSEEIFNNQ QLKPKSSNDN IVVNDEMTSI LNPKYTFDSF
     VIGNSNRFAH AASLAVAESP AKAYNPLFIY GGVGLGKTHL MHAIGHYILQ NTPNAKVVYV
     SSEKFTNELI NSIKDDKNEE FRNKYRNVDV LLIDDIQFIA GKERTQEEFF HTFNALYEAD
     KQIILSSDRP PKEIPTLEDR LRSRFEWGLI ADIQAPDFET RIAILKKKAD VENLDIPNEV
     MVYIATKIKS NIRELEGALI RIVAYSSLTN REISVDLAAE ALKDIISSEQ NKQITIELIQ
     DIVCNYFNLK IQELKSSRRT RNIAFPRQIA MYLSRKLTDM SLPKIGEEFG GRDHTTVIHA
     YEKISNILKK DESLRNVIDD LNKKITNN
//
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