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Database: UniProt
Entry: DNAA_CLOPE
LinkDB: DNAA_CLOPE
Original site: DNAA_CLOPE 
ID   DNAA_CLOPE              Reviewed;         457 AA.
AC   Q8XPG2;
DT   07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   07-JUN-2017, entry version 93.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=CPE0001;
OS   Clostridium perfringens (strain 13 / Type A).
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=195102;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=13 / Type A;
RX   PubMed=11792842; DOI=10.1073/pnas.022493799;
RA   Shimizu T., Ohtani K., Hirakawa H., Ohshima K., Yamashita A.,
RA   Shiba T., Ogasawara N., Hattori M., Kuhara S., Hayashi H.;
RT   "Complete genome sequence of Clostridium perfringens, an anaerobic
RT   flesh-eater.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:996-1001(2002).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
DR   EMBL; BA000016; BAB79707.1; -; Genomic_DNA.
DR   RefSeq; WP_003451025.1; NC_003366.1.
DR   ProteinModelPortal; Q8XPG2; -.
DR   SMR; Q8XPG2; -.
DR   EnsemblBacteria; BAB79707; BAB79707; BAB79707.
DR   GeneID; 29569836; -.
DR   KEGG; cpe:CPE0001; -.
DR   HOGENOM; HOG000235658; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000000818; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    457       Chromosomal replication initiator protein
FT                                DnaA.
FT                                /FTId=PRO_0000114166.
FT   NP_BIND     160    167       ATP. {ECO:0000255|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   457 AA;  52246 MW;  CF00761AC9041170 CRC64;
     MDAQLNNLWE QALNIIKGEI SEISFNTWIK SCTPISISDN ILKLSVPNEF TKGILDTRYK
     DLLIQALKIV TSRKFKIEFY LESDLEEEKE NEEKQKEEKK ENTNDVDGSI VVSDEMSATL
     NPKYTFQSFV IGNSNRFAHA ASLAVAESPA KAYNPLFIYG GVGLGKTHLM HAIGHYILQE
     NPKAKVVYVS SEKFTNELIN AIKDDKNEEF RNKYRKVDVL LIDDIQFIAG KERTQEEFFH
     TFNALHEENK QIILSSDRPP KEIPTLEDRL RSRFEWGLIA DIQPPDFETR MAILKKKADV
     EGLNVPNEVM VYIATKIKSN IRELEGALIR IIAYSSLTNR DVSVDLASEA LKDIISNKES
     APVTVKTIQE SVANYYNLRI EDLKSQRRTR NIAYPRQIAM YLSRKLTDMS LPKIGEEFGG
     RDHTTVIHAY EKISENLKTD EGLQSMINDI TKKLTQK
//
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