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Database: UniProt
Entry: DNAA_CORDI
LinkDB: DNAA_CORDI
Original site: DNAA_CORDI 
ID   DNAA_CORDI              Reviewed;         552 AA.
AC   Q6NKL7;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   07-JUN-2017, entry version 83.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=DIP0001;
OS   Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype
OS   gravis).
OC   Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC   Corynebacterium.
OX   NCBI_TaxID=257309;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700971 / NCTC 13129 / Biotype gravis;
RX   PubMed=14602910; DOI=10.1093/nar/gkg874;
RA   Cerdeno-Tarraga A.-M., Efstratiou A., Dover L.G., Holden M.T.G.,
RA   Pallen M.J., Bentley S.D., Besra G.S., Churcher C.M., James K.D.,
RA   De Zoysa A., Chillingworth T., Cronin A., Dowd L., Feltwell T.,
RA   Hamlin N., Holroyd S., Jagels K., Moule S., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Thomson N.R., Unwin L.,
RA   Whitehead S., Barrell B.G., Parkhill J.;
RT   "The complete genome sequence and analysis of Corynebacterium
RT   diphtheriae NCTC13129.";
RL   Nucleic Acids Res. 31:6516-6523(2003).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
DR   EMBL; BX248354; CAE48512.1; -; Genomic_DNA.
DR   ProteinModelPortal; Q6NKL7; -.
DR   SMR; Q6NKL7; -.
DR   EnsemblBacteria; CAE48512; CAE48512; DIP0001.
DR   KEGG; cdi:DIP0001; -.
DR   HOGENOM; HOG000235658; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   Proteomes; UP000002198; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    552       Chromosomal replication initiator protein
FT                                DnaA.
FT                                /FTId=PRO_0000114167.
FT   NP_BIND     252    259       ATP. {ECO:0000255|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   552 AA;  63030 MW;  AE3E2F38BE269971 CRC64;
     MWNETWNEIT NELIQLSREP ESEIPRITAE QRAYLKLVRP AAFVEGIAVL RVPHSRAKET
     IETHLGQAIT SVLSRRMGRP FTVAVTVDPT LDVIQDLPHD VPEQHIVQHH VPEHPHYSPV
     SQGYPPHYAP EQSEYNTEYS DEYPSGWATY HVQTPQPSQS SQSAQQQPAQ RMPDRRRYAE
     QQQVPQRSEE PVMGQRRARE KPAHDPDRNG SLNPRYTFDT YVVSDSNKLP WSAAWAVAEK
     PARAYNPLFI WGDSGLGKTH LMHAIGNYAQ ELDPKLKVKY VSSEEFTNDY INSVRDDRQE
     AFKRRYRDLD ILMVDDIQFL QGKEGTQEEF FHTFNALQQA DKQIVLSSDR PPKQLTTLED
     RLRTRFQSGL IADIYPPDLE TRIAILLNKA SAEGITADRD VLELIASRFN ASIRELEGAF
     IRVSAYASLN EAPINMATAQ EALRDMMPEQ ADIEITAGMI MSVTAEYFHI DVDTLKGSGK
     SRSVAHPRQL AMYLCRELTD LSLPKIGEHF GGKDHTTVMY AYRKIGKEIT EKRDTYDEIQ
     QLTQQIKSSD RA
//
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