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Database: UniProt
Entry: DNAA_COXBU
LinkDB: DNAA_COXBU
Original site: DNAA_COXBU 
ID   DNAA_COXBU              Reviewed;         451 AA.
AC   Q83FD8;
DT   07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-OCT-2017, entry version 90.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=CBU_0001;
OS   Coxiella burnetii (strain RSA 493 / Nine Mile phase I).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales;
OC   Coxiellaceae; Coxiella.
OX   NCBI_TaxID=227377;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RSA 493 / Nine Mile phase I;
RX   PubMed=12704232; DOI=10.1073/pnas.0931379100;
RA   Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E.,
RA   Nelson W.C., Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J.,
RA   DeBoy R.T., Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J.,
RA   Khouri H.M., Lee K.H., Carty H.A., Scanlan D., Heinzen R.A.,
RA   Thompson H.A., Samuel J.E., Fraser C.M., Heidelberg J.F.;
RT   "Complete genome sequence of the Q-fever pathogen, Coxiella
RT   burnetii.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
DR   EMBL; AE016828; AAO89571.1; -; Genomic_DNA.
DR   RefSeq; NP_819057.1; NC_002971.3.
DR   RefSeq; WP_005769932.1; NZ_CDBG01000001.1.
DR   ProteinModelPortal; Q83FD8; -.
DR   SMR; Q83FD8; -.
DR   STRING; 227377.CBU_0001; -.
DR   PRIDE; Q83FD8; -.
DR   EnsemblBacteria; AAO89571; AAO89571; CBU_0001.
DR   GeneID; 1207921; -.
DR   GeneID; 31482646; -.
DR   KEGG; cbu:CBU_0001; -.
DR   PATRIC; fig|227377.7.peg.2; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235659; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   Proteomes; UP000002671; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IBA:GO_Central.
DR   GO; GO:0006270; P:DNA replication initiation; IBA:GO_Central.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    451       Chromosomal replication initiator protein
FT                                DnaA.
FT                                /FTId=PRO_0000114170.
FT   NP_BIND     156    163       ATP. {ECO:0000255|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   451 AA;  51096 MW;  4615CFBF16DE0C5E CRC64;
     MSLPTSLWDK CLGYLRDEIP PQQYNTWIRP LHAIESKQNG LLLLAPNRFV LDWINERFLN
     RITELLDELS DTPPQIRLQI GSRSTEMPTK NSHEPSHRKA AAPPAGTTIS HTQANINSNF
     TFDSFVEGKS NQLARAAATQ VAENPGQAYN PLFIYGGVGL GKTHLMHAVG NAILRKDSSK
     KVLYLHSERF VADMIKALQH NAMNEFKRFY RSLNALLIDD IQFFAGKDRS QEEFFHTFNA
     LLDGQQQIIL TCDRYPKEIN GLEERLQSRF GWGLTVAIEP PELETRVAIL MSKAEQLKVH
     LPHEVAFFIA KHIQSNVREL EGALKRVIAN AHFTGQSITV DFTREALKDL LTLQARLITI
     ENIQKTVAEY YKIKVADLLA KRRNRSVARP RQMAMALAKE LTNHSLPEIG DAFGGRDHTT
     VLHACRKVKE LLATSLDILE DYKNLMRILS G
//
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