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Database: UniProt
Entry: DNAA_CUPMC
LinkDB: DNAA_CUPMC
Original site: DNAA_CUPMC 
ID   DNAA_CUPMC              Reviewed;         579 AA.
AC   Q1LSI9;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   07-JUN-2017, entry version 74.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=Rmet_0001;
OS   Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507
OS   / CH34) (Ralstonia metallidurans).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=266264;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43123 / DSM 2839 / NBRC 102507 / CH34;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Martinez M., Goltsman E., Pitluck S., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Kim E., Mergeay M., Benotmane M.A.,
RA   Vallaeys T., Michaux A., Monchy S., Dunn J., McCorkle S., Taghavi S.,
RA   van der Lelie D., Richardson P.;
RT   "Complete sequence of the chromosome of Ralstonia metallidurans
RT   CH34.";
RL   Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
DR   EMBL; CP000352; ABF06887.1; -; Genomic_DNA.
DR   RefSeq; WP_011514936.1; NC_007973.1.
DR   ProteinModelPortal; Q1LSI9; -.
DR   SMR; Q1LSI9; -.
DR   STRING; 266264.Rmet_0001; -.
DR   EnsemblBacteria; ABF06887; ABF06887; Rmet_0001.
DR   GeneID; 24151025; -.
DR   KEGG; rme:Rmet_0001; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235659; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000002429; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    579       Chromosomal replication initiator protein
FT                                DnaA.
FT                                /FTId=PRO_1000048700.
FT   NP_BIND     284    291       ATP. {ECO:0000255|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   579 AA;  63551 MW;  A886C87BD81EE857 CRC64;
     MQDFWQAAAA QLERELTPQQ FKTWIKPLAP VAFDEEAHAL RIAAPNRFKL DWVKSQFSGR
     ITALACEYWE TQVSVHFVLD PAASGRAAAY TQQAMQQGQD APAAMGTAMG AGHAPYPGMA
     GMAGGQSYGP AGAQVPGAHP NQMAGYPDYP SQSNGAPAGY GGAAGGQTPY SQSQQSAQGR
     GAAPTGHPLQ GNSAAHLPDM GEIDVAQMDP AEASARSYRV PSPQPAAPAG AQQQSDTVHE
     RSRLNPILTF DNFVTGKANQ LARAAAIQVA NNPGKSYNPL YLYGGVGLGK THLIHAIGNF
     MLMENPRARI RYIHAEQYVS DVVKAYQRKA FDEFKRYYHS LDLLLIDDIQ FFSGKNRTQE
     EFFYAFEALI ANRAQVIITS DTYPKEITGI DDRLISRFDS GLTVAIEPPE LEMRVAILMK
     KAAAENVSVP EEVAFFVAKH LRSNVRELEG ALRKILAFSN FHGKDITIDV TREALKDLLT
     VQNRQISVEN IQKTCADFYN IKVADMYSKK RPANIARPRQ IAMYLAKELT QKSLPEIGEL
     FGGRDHTTVL HAVRKIAEER SKDAQLNHEL HVLEQTLKG
//
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