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Database: UniProt
Entry: DNAA_CUPNH
LinkDB: DNAA_CUPNH
Original site: DNAA_CUPNH 
ID   DNAA_CUPNH              Reviewed;         588 AA.
AC   Q0KFR8;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   25-OCT-2017, entry version 73.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=H16_A0001;
OS   Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337)
OS   (Ralstonia eutropha).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=381666;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 17699 / H16 / DSM 428 / Stanier 337;
RX   PubMed=16964242; DOI=10.1038/nbt1244;
RA   Pohlmann A., Fricke W.F., Reinecke F., Kusian B., Liesegang H.,
RA   Cramm R., Eitinger T., Ewering C., Poetter M., Schwartz E.,
RA   Strittmatter A., Voss I., Gottschalk G., Steinbuechel A.,
RA   Friedrich B., Bowien B.;
RT   "Genome sequence of the bioplastic-producing 'Knallgas' bacterium
RT   Ralstonia eutropha H16.";
RL   Nat. Biotechnol. 24:1257-1262(2006).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
DR   EMBL; AM260479; CAJ91153.1; -; Genomic_DNA.
DR   RefSeq; WP_011614275.1; NC_008313.1.
DR   ProteinModelPortal; Q0KFR8; -.
DR   SMR; Q0KFR8; -.
DR   STRING; 381666.H16_A0001; -.
DR   EnsemblBacteria; CAJ91153; CAJ91153; H16_A0001.
DR   KEGG; reh:H16_A0001; -.
DR   PATRIC; fig|381666.6.peg.359; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235659; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   Proteomes; UP000008210; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    588       Chromosomal replication initiator protein
FT                                DnaA.
FT                                /FTId=PRO_1000048699.
FT   NP_BIND     293    300       ATP. {ECO:0000255|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   588 AA;  64647 MW;  59276B00F9F36C16 CRC64;
     MQDFWQAAAA QLERELTPQQ FKTWIKPLAP VAFDEETHAL RIAAPNRFKL DWVKSQFSGR
     ITALACEYWE AQVSVQFVLD PAASGRAAAY MQPAQPGMGP GGMDGHAAPG TGMGGYPGAQ
     PMGGQAMGQP PFAMPGQQPG YGYGEPVSAA GYGMGQPPYG NPGNPGNPAG MPSAAPVPAG
     ARGQPHPGQH GHQPHGADMG EIDVVQMDPA EASARSYRAP PQQPQQQPHQ QMGGATPMPG
     HQPSDTVHER SRLNPILTFD NFVTGKANQL ARAAAIQVAN NPGKSYNPLY LYGGVGLGKT
     HLIHAIGNFM LLENPRARIR YIHAEQYVSD VVKAYQRKAF DEFKRYYHSL DLLLIDDIQF
     FSGKNRTQEE FFYAFEALIA NRAQVIITSD TYPKEISGID DRLISRFDSG LTVAIEPPEL
     EMRVAILMKK AAAENVNVPE EVAFFVAKHL RSNVRELEGA LRKILAFSNF HGKDITIEVT
     REALKDLLTV QNRQISVENI QKTCADFYNI KVADMYSKKR PANIARPRQI AMYLAKELTQ
     KSLPEIGELF GGRDHTTVLH AVRKIADERS KDAQLNHELH VLEQTLKG
//
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