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Database: UniProt
Entry: DNAA_EHRRG
LinkDB: DNAA_EHRRG
Original site: DNAA_EHRRG 
ID   DNAA_EHRRG              Reviewed;         464 AA.
AC   Q5FHH8;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   07-JUN-2017, entry version 83.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=ERGA_CDS_02880;
OS   Ehrlichia ruminantium (strain Gardel).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Anaplasmataceae; Ehrlichia.
OX   NCBI_TaxID=302409;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Gardel;
RX   PubMed=16547041; DOI=10.1128/JB.188.7.2533-2542.2006;
RA   Frutos R., Viari A., Ferraz C., Morgat A., Eychenie S., Kandassamy Y.,
RA   Chantal I., Bensaid A., Coissac E., Vachiery N., Demaille J.,
RA   Martinez D.;
RT   "Comparative genomic analysis of three strains of Ehrlichia
RT   ruminantium reveals an active process of genome size plasticity.";
RL   J. Bacteriol. 188:2533-2542(2006).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
DR   EMBL; CR925677; CAI27740.1; -; Genomic_DNA.
DR   RefSeq; WP_011154971.1; NC_006831.1.
DR   ProteinModelPortal; Q5FHH8; -.
DR   SMR; Q5FHH8; -.
DR   EnsemblBacteria; CAI27740; CAI27740; ERGA_CDS_02880.
DR   KEGG; erg:ERGA_CDS_02880; -.
DR   HOGENOM; HOG000235660; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000000533; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    464       Chromosomal replication initiator protein
FT                                DnaA.
FT                                /FTId=PRO_0000114176.
FT   NP_BIND     170    177       ATP. {ECO:0000255|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   464 AA;  52675 MW;  E87D303D94EC069C CRC64;
     MNNDNTEVLE NYPQDGLQSN SHIIWKGIQS RLHKFYGNAI YDSWLSVLLY VSTESGKVLL
     SAPTRFIKEW ILVHYLDQIL KYWQDEDQSI CSVDICVVSN QDPNLLVDIK DRVDRGIKGN
     CDNVSSPLDP RFTFDNFVVG KPNELAFAAA RRVAESNSPI SGSNPLFLYG GVGLGKTHLM
     HAIAWYIIKS CSKRKIAYLS AEKFMYQYVT ALRSKDIMLF KEQFRSVDIL MVDDVQFISG
     KDSTQEEFFH TFNALIDQNK QLVISADRSP SDLDGVEERI KSRLGWGLVA DINETTFELR
     LGILQLKVEK MGINIPNKVL EFLAKNIKSN IRELEGALNK VVAHSSLVGC SITLDTASDI
     LSDLLRANHK SVTLECIQKK VAEFFNIKVS DMYSTRRLRT LARPRQIAMY LSKKLTQKSL
     PEIGKSFGGR DHATVIHAVK QIEKLMDTDS KLRDDINLLN RMLR
//
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