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Database: UniProt
Entry: DNAA_ENTFA
LinkDB: DNAA_ENTFA
Original site: DNAA_ENTFA 
ID   DNAA_ENTFA              Reviewed;         447 AA.
AC   Q839Z5;
DT   07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   07-JUN-2017, entry version 86.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=EF_0001;
OS   Enterococcus faecalis (strain ATCC 700802 / V583).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae;
OC   Enterococcus.
OX   NCBI_TaxID=226185;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700802 / V583;
RX   PubMed=12663927; DOI=10.1126/science.1080613;
RA   Paulsen I.T., Banerjei L., Myers G.S.A., Nelson K.E., Seshadri R.,
RA   Read T.D., Fouts D.E., Eisen J.A., Gill S.R., Heidelberg J.F.,
RA   Tettelin H., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J.,
RA   Daugherty S.C., DeBoy R.T., Durkin S.A., Kolonay J.F., Madupu R.,
RA   Nelson W.C., Vamathevan J.J., Tran B., Upton J., Hansen T., Shetty J.,
RA   Khouri H.M., Utterback T.R., Radune D., Ketchum K.A., Dougherty B.A.,
RA   Fraser C.M.;
RT   "Role of mobile DNA in the evolution of vancomycin-resistant
RT   Enterococcus faecalis.";
RL   Science 299:2071-2074(2003).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
DR   EMBL; AE016830; AAO79886.1; -; Genomic_DNA.
DR   RefSeq; NP_813814.1; NC_004668.1.
DR   RefSeq; WP_002356013.1; NZ_KE136524.1.
DR   ProteinModelPortal; Q839Z5; -.
DR   SMR; Q839Z5; -.
DR   STRING; 226185.EF0001; -.
DR   EnsemblBacteria; AAO79886; AAO79886; EF_0001.
DR   GeneID; 1198912; -.
DR   KEGG; efa:EF0001; -.
DR   PATRIC; fig|226185.45.peg.253; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   Proteomes; UP000001415; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    447       Chromosomal replication initiator protein
FT                                DnaA.
FT                                /FTId=PRO_0000114178.
FT   NP_BIND     151    158       ATP. {ECO:0000255|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   447 AA;  50409 MW;  72FCA0EF6EF590CA CRC64;
     MPDVESFWHS LEEAYQAILS APSFDAWIKT TRPLKLDNNQ LWLEVPSAVH RDYWEKNLSA
     KIVETGFKLT GAEVMPHFVV ADEKDAALAQ ELEEPAEEEV VFSEQSKKAM LNPKYTFDTF
     VIGKGNQMAH AAALVVAEDP GSIYNPLFFY GGVGLGKTHL MHAIGHQMLV NQPDAKVKYV
     SSETFTNEFI NSIQTKTSEQ FRKEYRNVDL LLVDDIQFLA EKEATLEEFF HTFNDLYNEN
     KQIVLTSDRP PNDIPKLPER LVSRFAWGLS VDITPPDLET RIAILRKKAD AERLEIPDDT
     LSYIAGQIDS NIRELEGALV RVQAFATING EDITTSLAAD ALKSLKSVGS KNQLSILQIQ
     EEVSKYYHVP LKDLKGKKRV KTIVVPRQIS MYLAREMTDN SLPKIGAEFG GKDHTTVIHA
     HEKIQQLLEK DPAIQKEVSE IKNLLNS
//
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