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Database: UniProt
Entry: DNAA_EXIS2
LinkDB: DNAA_EXIS2
Original site: DNAA_EXIS2 
ID   DNAA_EXIS2              Reviewed;         464 AA.
AC   B1YGB2;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   28-MAR-2018, entry version 62.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=Exig_0001;
OS   Exiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15).
OC   Bacteria; Firmicutes; Bacilli; Bacillales;
OC   Bacillales Family XII. Incertae Sedis; Exiguobacterium.
OX   NCBI_TaxID=262543;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17290 / JCM 13490 / 255-15;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Chertkov O.,
RA   Monk C., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.,
RA   Vishnivetskaya T., Rodrigues D.F., Gilichinsky D., Tiedje J.,
RA   Richardson P.;
RT   "Complete sequence of chromosome of Exiguobacterium sibiricum 255-
RT   15.";
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
DR   EMBL; CP001022; ACB59489.1; -; Genomic_DNA.
DR   RefSeq; WP_012368915.1; NC_010556.1.
DR   ProteinModelPortal; B1YGB2; -.
DR   SMR; B1YGB2; -.
DR   STRING; 262543.Exig_0001; -.
DR   EnsemblBacteria; ACB59489; ACB59489; Exig_0001.
DR   GeneID; 31768100; -.
DR   KEGG; esi:Exig_0001; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235658; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000001681; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    464       Chromosomal replication initiator protein
FT                                DnaA.
FT                                /FTId=PRO_1000121982.
FT   NP_BIND     167    174       ATP. {ECO:0000255|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   464 AA;  52421 MW;  081F272DE1A021B4 CRC64;
     MKNAAELWHN VLSVIEEEQR TPKASYDMWL KSTEGVTLNG TTLIVSAPAA FTVTWLERQY
     LSLLEDTVEE VTGSRLDIQF IEEGQAKHML DRQNEEVEVM EVAPAKTKAQ KTPKSSDELV
     MSELGQLNEK YTFDTFVIGS GNRFAHAASL AVAEAPAKAY NPLFIYGGVG LGKTHLMHAI
     GQYVQDQKLG TKIAYVSSEQ FTNDFINSIR DNKTVQFRNK YRNIDVLLID DIQFLAGKEQ
     TQEEFFHTFN ALHNDQKQII ISSDRPPKEI PTLEDRLRSR FEWGLITDIT PPDLETRIAI
     LRKKANAEQL DVSNEVMLYI ASQIDTNIRE LEGALTRVIA YANLVGRTID PNVAAEALHN
     IMPASEPRKV TIRDIQESVS KHFNLPFDDL KAKKRTKSIA FPRQIAMYLS REMTESSLPK
     IGEEFGGRDH TTVIHAHEKI STLVKSDGET GKVIEQIKHE LKHS
//
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