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Database: UniProt
Entry: DNAA_EXISA
LinkDB: DNAA_EXISA
Original site: DNAA_EXISA 
ID   DNAA_EXISA              Reviewed;         459 AA.
AC   C4KZZ3;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   07-JUL-2009, sequence version 1.
DT   28-MAR-2018, entry version 55.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=EAT1b_1730;
OS   Exiguobacterium sp. (strain ATCC BAA-1283 / AT1b).
OC   Bacteria; Firmicutes; Bacilli; Bacillales;
OC   Bacillales Family XII. Incertae Sedis; Exiguobacterium.
OX   NCBI_TaxID=360911;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1283 / AT1b;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T.,
RA   Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Ovchinnikova G., Ramaley R.F., Rodrigues D.F., Vishnivetskaya T.A.,
RA   Kathariou S., Tiedje J.M., Richardson P.;
RT   "Complete sequence of Exiguobacterium sp. AT1b.";
RL   Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
DR   EMBL; CP001615; ACQ70656.1; -; Genomic_DNA.
DR   RefSeq; WP_015880215.1; NC_012673.1.
DR   ProteinModelPortal; C4KZZ3; -.
DR   SMR; C4KZZ3; -.
DR   STRING; 360911.EAT1b_1730; -.
DR   EnsemblBacteria; ACQ70656; ACQ70656; EAT1b_1730.
DR   KEGG; eat:EAT1b_1730; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235658; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; POG091H02FF; -.
DR   BioCyc; ESP360911:G1GVI-1760-MONOMER; -.
DR   Proteomes; UP000000716; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    459       Chromosomal replication initiator protein
FT                                DnaA.
FT                                /FTId=PRO_1000205652.
FT   NP_BIND     163    170       ATP. {ECO:0000255|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   459 AA;  51868 MW;  64CBC7D01765B535 CRC64;
     MKNAREIWRN VLSVIEEEER TPKASFDMWL KSTEGISLMG TTLVVSAPAS FIVTWLERQY
     LSLLQDTVEE ITNNKLEIHF IEESQAHKYA PADGSSNESI AVTETKEQPV LLPSKEEGDL
     GQLNDKYIFE TFVIGSGNRF AHAASLAVAE APARAYNPLF IYGGVGLGKT HLMHAIGHYV
     KGQKPGARIA YVSSEKFTNE FINSIRDNKT GEFRNRYRNI DVLLIDDIQF LAGKEQTQEE
     FFHTFNALHN DQKQIVISSD RPPKEIPTLE DRLRSRFEWG LITDITPPDL ETRIAILRKK
     ATAEGLDISN EVMLYIANQI DTNIRELEGA LTRVVAYAKL VGRPIDPDVA AEALHNIMPV
     QEAKKIVIRD IQEVVGQHFN IQVEELNSKK RTKTLAFPRQ IAMYLSREMT ESSLPKIGEE
     FGGRDHTTVI HAHEKISTLL KNDVEMQETI QTLKKALSN
//
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