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Database: UniProt
Entry: DNAA_GEOSW
LinkDB: DNAA_GEOSW
Original site: DNAA_GEOSW 
ID   DNAA_GEOSW              Reviewed;         450 AA.
AC   C5D327;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-OCT-2017, entry version 53.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=GWCH70_0001;
OS   Geobacillus sp. (strain WCH70).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus.
OX   NCBI_TaxID=471223;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WCH70;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T.,
RA   Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Brumm P., Mead D.A., Richardson P.;
RT   "Complete sequence of chromosome of Geopacillus sp. WCH70.";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
DR   EMBL; CP001638; ACS22943.1; -; Genomic_DNA.
DR   RefSeq; WP_012748780.1; NC_012793.1.
DR   ProteinModelPortal; C5D327; -.
DR   SMR; C5D327; -.
DR   STRING; 471223.GWCH70_0001; -.
DR   EnsemblBacteria; ACS22943; ACS22943; GWCH70_0001.
DR   KEGG; gwc:GWCH70_0001; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235658; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000002386; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    450       Chromosomal replication initiator protein
FT                                DnaA.
FT                                /FTId=PRO_1000205654.
FT   NP_BIND     153    160       ATP. {ECO:0000255|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   450 AA;  51644 MW;  473659B8DEFC1BD7 CRC64;
     MENIHDLWNR VLGEIEKKIS KPSFETWLKS TKAHSLRGDT LVIIAPNEFA RDWLDSRYSR
     LIAETIYDIT GEELLIKFIT PPNQSEDDFE FQRSSKKHRK PYEESTDFPQ SMLNPKYTFD
     TFVIGSGNRF AHAASLAVAE APAKAYNPLF IYGGVGLGKT HLMHAIGHYV IEHNPSAKVV
     YLSSEKFTNE FINAIRDNRP DDFRNKYRNV DVLLIDDIQF LAGKEQTQEE FFHTFNTLHE
     ESKQIVISSD RPPKEIPTLE DRLRSRFEWG LITDITPPDL ETRIAILRKK AKAEGFDIPN
     EVMLYIANQI DSNIRELEGA LIRVVAYSSL INKEITADLA AEALKDIIPS TKPKVITIQD
     IQRVVGQHFN IKLEDFKAKK RTKSVAFPRQ IAMYLSRELT DCSLPKIGDE FGGRDHTTVI
     HAHEKISKLL QTDAQLQKHI KEIEEKLKQL
//
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