GenomeNet

Database: UniProt
Entry: DNAA_HAEIN
LinkDB: DNAA_HAEIN
Original site: DNAA_HAEIN 
ID   DNAA_HAEIN              Reviewed;         454 AA.
AC   P43742;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   07-JUN-2017, entry version 111.
DE   RecName: Full=Chromosomal replication initiator protein DnaA;
GN   Name=dnaA; OrderedLocusNames=HI_0993;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M.,
RA   Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D.,
RA   Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C.,
RA   Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M.,
RA   Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O.,
RA   Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000305}.
DR   EMBL; L42023; AAC22655.1; -; Genomic_DNA.
DR   PIR; B64107; B64107.
DR   RefSeq; NP_439156.1; NC_000907.1.
DR   RefSeq; WP_005693336.1; NC_000907.1.
DR   ProteinModelPortal; P43742; -.
DR   SMR; P43742; -.
DR   STRING; 71421.HI0993; -.
DR   EnsemblBacteria; AAC22655; AAC22655; HI_0993.
DR   GeneID; 950755; -.
DR   KEGG; hin:HI0993; -.
DR   PATRIC; fig|71421.8.peg.1036; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   PhylomeDB; P43742; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IBA:GO_Central.
DR   GO; GO:0006270; P:DNA replication initiation; IBA:GO_Central.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    454       Chromosomal replication initiator protein
FT                                DnaA.
FT                                /FTId=PRO_0000114186.
FT   NP_BIND     160    167       ATP. {ECO:0000255}.
SQ   SEQUENCE   454 AA;  51724 MW;  B7ED007B48433A65 CRC64;
     MNLSNLWQSC LLQLQDQVSA SDLSTWLRPL QADVVADNHI VLYASNMFVK GWVETHYLAQ
     IQQICQTLAQ NPELRISLKE GVKPAPKIVE STPNTSLRSE SAVDFQAESS ASVKFESHLN
     TKHLFDNFVE GKSNQLARAV GQKLAQAPGE PSANPFFLYG GTGLGKTHLL HAIGNGILAD
     KPNARVLYIH ANNFMQHMVK AVRDNKMDQF KKFYRSLDAL LVDDIQFFAE KEKTQEEFFH
     IFNSLFETGR QIILTSDRYP KEIEKIEERL KSRFGWGLTT AIEPPDLETR VAILLKKAEE
     HNMNLPEEVA FFIAQRLRTN VRELEGALNR VKAMQDFKGG DIDIDFVRDT LKDILALQER
     LVTIENIQKV VAEYYRIKVS DLKSKSRARS VTRPRQIAMA LAKELTNRSL PEIGRAFDRD
     HTTVLNACRE VPKFREQDNS IQEDWANLIR TLSA
//
DBGET integrated database retrieval system