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Database: UniProt
Entry: DNAA_HELMI
LinkDB: DNAA_HELMI
Original site: DNAA_HELMI 
ID   DNAA_HELMI              Reviewed;         443 AA.
AC   B0TAK8;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   07-JUN-2017, entry version 63.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=Helmi_10350; ORFNames=HM1_0905;
OS   Heliobacterium modesticaldum (strain ATCC 51547 / Ice1).
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Heliobacteriaceae;
OC   Heliobacterium.
OX   NCBI_TaxID=498761;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51547 / Ice1;
RX   PubMed=18441057; DOI=10.1128/JB.00299-08;
RA   Sattley W.M., Madigan M.T., Swingley W.D., Cheung P.C., Clocksin K.M.,
RA   Conrad A.L., Dejesa L.C., Honchak B.M., Jung D.O., Karbach L.E.,
RA   Kurdoglu A., Lahiri S., Mastrian S.D., Page L.E., Taylor H.L.,
RA   Wang Z.T., Raymond J., Chen M., Blankenship R.E., Touchman J.W.;
RT   "The genome of Heliobacterium modesticaldum, a phototrophic
RT   representative of the Firmicutes containing the simplest
RT   photosynthetic apparatus.";
RL   J. Bacteriol. 190:4687-4696(2008).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
DR   EMBL; CP000930; ABZ83660.1; -; Genomic_DNA.
DR   RefSeq; WP_012282183.1; NC_010337.2.
DR   ProteinModelPortal; B0TAK8; -.
DR   SMR; B0TAK8; -.
DR   STRING; 498761.HM1_0905; -.
DR   EnsemblBacteria; ABZ83660; ABZ83660; HM1_0905.
DR   KEGG; hmo:HM1_0905; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235658; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000008550; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    443       Chromosomal replication initiator protein
FT                                DnaA.
FT                                /FTId=PRO_1000121984.
FT   NP_BIND     146    153       ATP. {ECO:0000255|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   443 AA;  50374 MW;  D1C184CE24CA78B2 CRC64;
     MTSQFASLWQ QSLEILKQEL KPASFDTWLK NTQLVTIQNG EAHIGVPNDL ARDWLENRYA
     TLVKNALSVV LGESVEVRFF TPSADSRRSE PSRRPVATEE SSPPLLNPKY TFDTFVVGNS
     NRFAHAAALA VAEAPAKAYN PLFVYGGVGL GKTHLMQAIG HFVIEQHPQS RVVYVSSEKF
     TNELINAIRD DKTVEFRNRY RNIDVLLIDD IQFLAGKERT QEEFFHTFNA LHESSKQIII
     SSDRPPKEIP TLEDRLRSRF EWGLITDINP PDLETRIAIL RKKAILENLD VPNEVMVFIA
     NIIQSNIREL EGALNRVIAY ANLSGKSLTS EVAEEALKNI IPSHRAKVIT IALIQEIVAE
     HYNMRVEDFK AKKRTRDVAF PRQIAMYLSR EMLDVSLPKI GEEFGGRDHT TVIHAHEKIT
     KDIEKDPQLE MTIQVLKEKI QRA
//
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