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Database: UniProt
Entry: DNAA_LACDA
LinkDB: DNAA_LACDA
Original site: DNAA_LACDA 
ID   DNAA_LACDA              Reviewed;         454 AA.
AC   Q1GC43;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   27-JUN-2006, sequence version 1.
DT   07-JUN-2017, entry version 73.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=Ldb0001;
OS   Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM
OS   20081 / JCM 1002 / NBRC 13953 / NCIMB 11778).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=390333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11842 / DSM 20081 / JCM 1002 / NBRC 13953 / NCIMB 11778;
RX   PubMed=16754859; DOI=10.1073/pnas.0603024103;
RA   van de Guchte M., Penaud S., Grimaldi C., Barbe V., Bryson K.,
RA   Nicolas P., Robert C., Oztas S., Mangenot S., Couloux A., Loux V.,
RA   Dervyn R., Bossy R., Bolotin A., Batto J.-M., Walunas T.,
RA   Gibrat J.-F., Bessieres P., Weissenbach J., Ehrlich S.D., Maguin E.;
RT   "The complete genome sequence of Lactobacillus bulgaricus reveals
RT   extensive and ongoing reductive evolution.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:9274-9279(2006).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
DR   EMBL; CR954253; CAI96847.1; -; Genomic_DNA.
DR   RefSeq; WP_003622141.1; NZ_JQAV01000011.1.
DR   ProteinModelPortal; Q1GC43; -.
DR   SMR; Q1GC43; -.
DR   STRING; 390333.Ldb0001; -.
DR   EnsemblBacteria; CAI96847; CAI96847; Ldb0001.
DR   GeneID; 4084568; -.
DR   KEGG; ldb:Ldb0001; -.
DR   PATRIC; fig|390333.13.peg.529; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235658; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   Proteomes; UP000001259; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    454       Chromosomal replication initiator protein
FT                                DnaA.
FT                                /FTId=PRO_1000048661.
FT   NP_BIND     158    165       ATP. {ECO:0000255|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   454 AA;  51559 MW;  0E846A674CDD2145 CRC64;
     MFDLEKFWDS FNAEMRSEFN EVSYNAWFKN TKPVSFNKDT HELVISVQTP VAKGYWEQNI
     SANLIQSAYA YAGIDIYPVF VVKNGPTPSS ERMLEPQPQA KPEKARPQGR EFTKDLRLNE
     KYTFENFIQG EGNKLAAGAA LAVADNPGTF YNPLFIFGGV GLGKTHLMQA IGHQMLAERP
     DAKVVYIQSE TFVNDFINSI KNKTQDKFRE KYRTADLLLV DDIQFFAKKE GIQEEFFHTF
     ETLYNDQKQI VMTSDRLPTE IPDLSERLVS RFAWGLQVEI TPPDLETRIA ILRKKAESEG
     LEIDESTLDY VASQVDTNIR ELEGALVKVQ AQATIQKQDI NIGLARSALA DLKLVQKSRG
     LQISKIQEVV ANYFQTSVPD LKGKKRVRQI VIPRQIAMYL SRELTDASLP KIGQEFGGKD
     HTTVMHACDK IARQIKTDTE IKSAVSDLRQ MLER
//
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