GenomeNet

Database: UniProt
Entry: DNAA_METFK
LinkDB: DNAA_METFK
Original site: DNAA_METFK 
ID   DNAA_METFK              Reviewed;         470 AA.
AC   Q1GXK1;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   27-JUN-2006, sequence version 1.
DT   30-AUG-2017, entry version 75.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=Mfla_0001;
OS   Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Nitrosomonadales;
OC   Methylophilaceae; Methylobacillus.
OX   NCBI_TaxID=265072;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KT / ATCC 51484 / DSM 6875;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Saunders E.,
RA   Gilna P., Schmutz J., Larimer F., Land M., Kyrpides N., Anderson I.,
RA   Richardson P.;
RT   "Complete sequence of Methylobacillus flagellatus KT.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
DR   EMBL; CP000284; ABE48272.1; -; Genomic_DNA.
DR   RefSeq; WP_011478369.1; NC_007947.1.
DR   ProteinModelPortal; Q1GXK1; -.
DR   SMR; Q1GXK1; -.
DR   STRING; 265072.Mfla_0001; -.
DR   EnsemblBacteria; ABE48272; ABE48272; Mfla_0001.
DR   KEGG; mfa:Mfla_0001; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235659; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000002440; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    470       Chromosomal replication initiator protein
FT                                DnaA.
FT                                /FTId=PRO_1000048670.
FT   NP_BIND     175    182       ATP. {ECO:0000255|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   470 AA;  53071 MW;  93505A970A0A5E13 CRC64;
     MENFWSLCLG RFEEELSAQQ FNTWIKPLRF EAREGTLRLL APNRFVQQWV KDRFLQKISA
     LAEEVLSTPV QIELALYDAS EKSPITLAKP KPAEAPGAAA KIEAEISKVT KTVSPAKPAS
     AAPKKPKTLT ETSGLNPAFR FDNFVTGKAN QLARAAAIQV AENPGTAYNP LFIYGGVGLG
     KTHVLQAIGN HLKSQRPDAK IRYLHAERYV SDVVKAYEHK AFDEFKRQYH SLDLLLIDDI
     QFFAKKSRTQ EEFFYAFNSL IEAKKQIIIT CDTYPKEIAD VDERLRTRFS WGLTVAVEPP
     ELEMRVAILL KKAEAARVTL DEDVAFFIAK QVRSSVRELE GALNRIIAMA NFTGHAIDVS
     LAKEALKDLI AVRGRQITIE NIQKTVADYY KIKVAEMYSK KRSRNFARPR QIAMTLAREL
     TNHSFPEIGE AFGGRHHTTV MHACDEIEQL RQNDQNVARD IAVLIQVIRD
//
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