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Database: UniProt
Entry: DNAA_MYCGE
LinkDB: DNAA_MYCGE
Original site: DNAA_MYCGE 
ID   DNAA_MYCGE              Reviewed;         437 AA.
AC   P35888; Q49363;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 2.
DT   25-OCT-2017, entry version 118.
DE   RecName: Full=Chromosomal replication initiator protein DnaA;
GN   Name=dnaA; OrderedLocusNames=MG469;
OS   Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=243273;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33530 / G-37 / NCTC 10195;
RX   PubMed=7569993; DOI=10.1126/science.270.5235.397;
RA   Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A.,
RA   Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M.,
RA   Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L.,
RA   Nguyen D.T., Utterback T.R., Saudek D.M., Phillips C.A., Merrick J.M.,
RA   Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S.,
RA   Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C.;
RT   "The minimal gene complement of Mycoplasma genitalium.";
RL   Science 270:397-403(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 183-281 AND 286-402.
RC   STRAIN=ATCC 33530 / G-37 / NCTC 10195;
RX   PubMed=8253680; DOI=10.1128/jb.175.24.7918-7930.1993;
RA   Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III;
RT   "A survey of the Mycoplasma genitalium genome by using random
RT   sequencing.";
RL   J. Bacteriol. 175:7918-7930(1993).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000305}.
DR   EMBL; L43967; AAC72490.1; -; Genomic_DNA.
DR   EMBL; U02259; AAD12524.1; -; Genomic_DNA.
DR   EMBL; U02145; AAD12425.1; -; Genomic_DNA.
DR   PIR; H64251; H64251.
DR   RefSeq; WP_010869493.1; NC_000908.2.
DR   PDB; 2JMP; NMR; -; A=1-100.
DR   PDBsum; 2JMP; -.
DR   ProteinModelPortal; P35888; -.
DR   SMR; P35888; -.
DR   EnsemblBacteria; AAC72490; AAC72490; MG_469.
DR   KEGG; mge:MG_469; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; POG091H02FF; -.
DR   EvolutionaryTrace; P35888; -.
DR   Proteomes; UP000000807; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.20; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR015946; KH_dom-like_a/b.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   1: Evidence at protein level;
KW   3D-structure; ATP-binding; Complete proteome; Cytoplasm;
KW   DNA replication; DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    437       Chromosomal replication initiator protein
FT                                DnaA.
FT                                /FTId=PRO_0000114211.
FT   NP_BIND     141    148       ATP. {ECO:0000255}.
FT   CONFLICT    198    198       E -> G (in Ref. 2; AAD12524).
FT                                {ECO:0000305}.
FT   HELIX         2     14       {ECO:0000244|PDB:2JMP}.
FT   HELIX        19     24       {ECO:0000244|PDB:2JMP}.
FT   TURN         25     28       {ECO:0000244|PDB:2JMP}.
FT   STRAND       32     34       {ECO:0000244|PDB:2JMP}.
FT   STRAND       36     42       {ECO:0000244|PDB:2JMP}.
FT   HELIX        46     54       {ECO:0000244|PDB:2JMP}.
FT   HELIX        59     62       {ECO:0000244|PDB:2JMP}.
FT   TURN         63     65       {ECO:0000244|PDB:2JMP}.
FT   STRAND       71     75       {ECO:0000244|PDB:2JMP}.
FT   HELIX        77     85       {ECO:0000244|PDB:2JMP}.
SQ   SEQUENCE   437 AA;  50762 MW;  D4DF45A0F4768ED6 CRC64;
     MEQFNAFKSL LKKHYEKTIG FHDKYIKDIN RFVFKNNVLL ILLENEFARN SLNDNSEIIH
     LAESLYEGIK SVNFVNEQDF FFNLAKLEEN SRDTLYQNSG LSKNYTFQNF VISEGNKRAY
     EAGVRLAETQ DNEFSPLFIY GETGLGKTHL LQAIGNEKFR NFPNARVKYV VSSDFAQEVV
     DAFYQRDKGI EKLKKNYENL DLVLIDDTQI FGRKEKTLEI LFNIFNNLVL NKKQIVLVSD
     KAPDELIDID ARMISRFKSG LLLKIEKHNL SSLCEILTVK LKEKDPNIQI TNEARHDAAQ
     ISGNDVRALN GIATKLLFFA KTSKQNLINT ENLKEILFEE FEKFHKKSFD PYLLIENVCR
     RFNVPMDSVL SENRKAELVR VRDVCNYLLR QKYNMQFQQI GKIFKRSHSS VLMAVKRVAK
     MIENDSSLRD VITSLVI
//
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