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Database: UniProt
Entry: DNAA_MYCPN
LinkDB: DNAA_MYCPN
Original site: DNAA_MYCPN 
ID   DNAA_MYCPN              Reviewed;         439 AA.
AC   Q59549;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-OCT-2017, entry version 105.
DE   RecName: Full=Chromosomal replication initiator protein DnaA;
GN   Name=dnaA; OrderedLocusNames=MPN_686; ORFNames=MP156;
OS   Mycoplasma pneumoniae (strain ATCC 29342 / M129).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=272634;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 29342 / M129;
RX   PubMed=8604303; DOI=10.1093/nar/24.4.628;
RA   Hilbert H., Himmelreich R., Plagens H., Herrmann R.;
RT   "Sequence analysis of 56 kb from the genome of the bacterium
RT   Mycoplasma pneumoniae comprising the dnaA region, the atp operon and a
RT   cluster of ribosomal protein genes.";
RL   Nucleic Acids Res. 24:628-639(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29342 / M129;
RX   PubMed=8948633; DOI=10.1093/nar/24.22.4420;
RA   Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C.,
RA   Herrmann R.;
RT   "Complete sequence analysis of the genome of the bacterium Mycoplasma
RT   pneumoniae.";
RL   Nucleic Acids Res. 24:4420-4449(1996).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000305}.
DR   EMBL; U34816; AAC43648.1; -; Genomic_DNA.
DR   EMBL; U00089; AAB95804.1; -; Genomic_DNA.
DR   PIR; S62793; S62793.
DR   RefSeq; NP_110375.1; NC_000912.1.
DR   RefSeq; WP_010875043.1; NC_000912.1.
DR   ProteinModelPortal; Q59549; -.
DR   SMR; Q59549; -.
DR   IntAct; Q59549; 3.
DR   EnsemblBacteria; AAB95804; AAB95804; MPN_686.
DR   GeneID; 877037; -.
DR   KEGG; mpn:MPN686; -.
DR   PATRIC; fig|272634.6.peg.753; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   Proteomes; UP000000808; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.20; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR015946; KH_dom-like_a/b.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    439       Chromosomal replication initiator protein
FT                                DnaA.
FT                                /FTId=PRO_0000114216.
FT   NP_BIND     141    148       ATP. {ECO:0000255}.
SQ   SEQUENCE   439 AA;  50624 MW;  931A42DEB2A07ECA CRC64;
     MEQFSAFKLL LKKQYETTLG FYDKYIKNLK RFALKNNVLF VIVDNEFARE TLNSNPDIVG
     LASKLYDDIR AVRFVNEQDF FINLAKLEED NRETLYQSSG LSKNFTFKNF VVGDGNRRVY
     EAGVRISETQ DADFSPLFIY GETGLGKTHL LQAIGNDKFF HFPNAKVKYV VSSDFAQEVV
     NAFYQKEKDQ GIEKLKAAYE SLDLLLIDDT QIFGKKEKTL EILFSIFNNL VSKGKQIVFV
     SDKTPDELAN IDPRMVSRFK SGLLLKIEKH NLSSLCEILA VKLKEKDPNI QITNEAREKA
     AQISGNDVRS LNGIATKLLF YVKTTKQNLI NNDNLKEILF EEFEKFHKKS FDPYLLIENV
     CRRFNVPVDS VLSENRKAEL VRVRDVCNYI LREKYKMQFQ QIGKIFKRNH STVVAAVKRV
     AKMIEKDDSL QDIITSLVI
//
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