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Database: UniProt
Entry: DNAA_MYCSK
LinkDB: DNAA_MYCSK
Original site: DNAA_MYCSK 
ID   DNAA_MYCSK              Reviewed;         495 AA.
AC   A1U8S0;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   05-JUL-2017, entry version 69.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=Mkms_0009;
OS   Mycobacterium sp. (strain KMS).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=189918;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KMS;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P.,
RA   Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Miller C.D., Richardson P.;
RT   "Complete sequence of chromosome of Mycobacterium sp. KMS.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
DR   EMBL; CP000518; ABL89228.1; -; Genomic_DNA.
DR   RefSeq; WP_011557429.1; NC_008705.1.
DR   ProteinModelPortal; A1U8S0; -.
DR   SMR; A1U8S0; -.
DR   EnsemblBacteria; ABL89228; ABL89228; Mkms_0009.
DR   GeneID; 32418907; -.
DR   KEGG; mkm:Mkms_0009; -.
DR   HOGENOM; HOG000235658; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000000638; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    495       Chromosomal replication initiator protein
FT                                DnaA.
FT                                /FTId=PRO_1000048672.
FT   NP_BIND     196    203       ATP. {ECO:0000255|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   495 AA;  55645 MW;  CA67241F800798EB CRC64;
     MTADPDPPFV AVWNTVVAEL NGDPAATGPR NGDGALPTLT PQQRAWLKLV KPLVITEGFA
     LLSVPTPFVQ NEIERHLREP IITALSRHLG QRVELGVRIA TPSPEDDDPP PSPVIADIDE
     VDEDTEARVS AEETWPRYFS RPPETPAAED PNAVSLNRRY TFDTFVIGAS NRFAHAATLA
     IAEAPARAYN PLFIWGESGL GKTHLLHAAG NYAQRLFPGM RVKYVSTEEF TNDFINSLRD
     DRKASFKRSY RDIDVLLVDD IQFIEGKEGI QEEFFHTFNT LHNANKQIVI SSDRPPKQLA
     TLEDRLRTRF EWGLITDVQP PELETRIAIL RKKAQMDRLD VPDDVLELIA SSIERNIREL
     EGALIRVTAF ASLNKTPIDK SLAEIVLRDL ISDASTMQIS TAAIMAATAE YFETTIEELR
     GPGKTRALAQ SRQIAMYLCR ELTDLSLPKI GQAFGRDHTT VMYAEKKIRG EMAERREVFD
     HVKELTTRIR QRAKR
//
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