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Database: UniProt
Entry: DNAA_NITHX
LinkDB: DNAA_NITHX
Original site: DNAA_NITHX 
ID   DNAA_NITHX              Reviewed;         475 AA.
AC   Q1QS94;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   25-OCT-2017, entry version 78.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=Nham_0001;
OS   Nitrobacter hamburgensis (strain DSM 10229 / NCIMB 13809 / X14).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Bradyrhizobiaceae; Nitrobacter.
OX   NCBI_TaxID=323097;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 10229 / NCIMB 13809 / X14;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Ward B.,
RA   Arp D., Klotz M., Stein L., O'Mullan G., Starkenburg S., Sayavedra L.,
RA   Poret-Peterson A.T., Gentry M.E., Bruce D., Richardson P.;
RT   "Complete sequence of chromosome of Nitrobacter hamburgensis X14.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
DR   EMBL; CP000319; ABE60903.1; -; Genomic_DNA.
DR   RefSeq; WP_011508610.1; NC_007964.1.
DR   ProteinModelPortal; Q1QS94; -.
DR   SMR; Q1QS94; -.
DR   STRING; 323097.Nham_0001; -.
DR   PRIDE; Q1QS94; -.
DR   EnsemblBacteria; ABE60903; ABE60903; Nham_0001.
DR   KEGG; nha:Nham_0001; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235660; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000001953; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    475       Chromosomal replication initiator protein
FT                                DnaA.
FT                                /FTId=PRO_1000048679.
FT   NP_BIND     176    183       ATP. {ECO:0000255|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   475 AA;  52756 MW;  F79E45C4F4729069 CRC64;
     MSDIEQERWS RVKGRLRSTV GEDIYSSWFA RMDLESVHGE SVRMSVPTRF LKSWIQAHYA
     ERVLACWQAE LPDVHRIDLM VRSAMRCAAP AKEAPAADPR RPEHGDGRAS TELKMVATAP
     ASANHDALGG SPLDPRLTFA SFVTGRSNTL AHAAARQVAE GRRGDSIMFN PLYIHAGVGL
     GKTHLLQAVT WAGNAGTERK VLYLTAEKFM YGFVAALKSQ TALAFKEALR GIDVLVIDDL
     QFLQGKSTQA EFCHTLNALI DAGRQVVVAA DRPPSDLESL DDRVRSRLAG GLVVEMGSLG
     EELRLGILKS RIEVARAHHA SFSVPEPVLD YLAKAITHNG RDLEGAINRL LAHSKLNAQP
     VTLEMAEREV RDLIRPQEPR RIKIEDIQRV VARQYNVSRS DLLSSRRTAN VVRPRQVAMY
     LAKTLTLRSL PEIGRRFGGR DHTTVLHAVR KIEALVSKDT TLSDEVELLK RQLQE
//
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