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Database: UniProt
Entry: DNAA_NITWN
LinkDB: DNAA_NITWN
Original site: DNAA_NITWN 
ID   DNAA_NITWN              Reviewed;         475 AA.
AC   Q3SMV0;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   25-OCT-2017, entry version 83.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=Nwi_0001;
OS   Nitrobacter winogradskyi (strain ATCC 25391 / DSM 10237 / CIP 104748 /
OS   NCIMB 11846 / Nb-255).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Bradyrhizobiaceae; Nitrobacter.
OX   NCBI_TaxID=323098;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25391 / DSM 10237 / CIP 104748 / NCIMB 11846 / Nb-255;
RX   PubMed=16517654; DOI=10.1128/AEM.72.3.2050-2063.2006;
RA   Starkenburg S.R., Chain P.S.G., Sayavedra-Soto L.A., Hauser L.,
RA   Land M.L., Larimer F.W., Malfatti S.A., Klotz M.G., Bottomley P.J.,
RA   Arp D.J., Hickey W.J.;
RT   "Genome sequence of the chemolithoautotrophic nitrite-oxidizing
RT   bacterium Nitrobacter winogradskyi Nb-255.";
RL   Appl. Environ. Microbiol. 72:2050-2063(2006).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
DR   EMBL; CP000115; ABA03269.1; -; Genomic_DNA.
DR   RefSeq; WP_011313340.1; NC_007406.1.
DR   ProteinModelPortal; Q3SMV0; -.
DR   SMR; Q3SMV0; -.
DR   STRING; 323098.Nwi_0001; -.
DR   EnsemblBacteria; ABA03269; ABA03269; Nwi_0001.
DR   KEGG; nwi:Nwi_0001; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235660; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000002531; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    475       Chromosomal replication initiator protein
FT                                DnaA.
FT                                /FTId=PRO_1000048682.
FT   NP_BIND     176    183       ATP. {ECO:0000255|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   475 AA;  52924 MW;  19A8F4F5CACFB646 CRC64;
     MSDTEQERWS RVKGRLRSTV GEDIYSSWFA RMDLESVHGE SVRLSVPTRF LKSWIQAHYA
     ERVLSCWQAE LPDVHRIDLT VRSAMRCAAP VREAPATDAR HPERSEGRNG VELKTVATAP
     ASANHDALGG SPLDPRLTFQ SFVTGRSNTL AHAAARQVAE GRRGDSVMFN PLYIHAGVGL
     GKTHLLQAVT WAGNAGTERR VLYLTAEKFM YGFVAALKTQ TALAFKEALR GIDVLVIDDL
     QFLQGKSTQA EFCHTLNALI DAGRQVVIAA DRPPSDLESL DDRVRSRLAG GLVVEMGSLG
     EELRLGILRS RVEAARVHHA SFDVPEPVLD YLAKAITHNG RDLEGAINRL LAHSKLNAQP
     VTLEMAEREV RDLVRPQEPR RIKIEDIQRV VARQYNVSRS DLLSSRRTAN VVRPRQVAMY
     LAKTLTLRSL PEIGRRFGGR DHTTVLHAVR KIEALVSKDT TLSDEVELLK RQLQE
//
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