GenomeNet

Database: UniProt
Entry: DNAA_PHYMT
LinkDB: DNAA_PHYMT
Original site: DNAA_PHYMT 
ID   DNAA_PHYMT              Reviewed;         455 AA.
AC   B3R0L6;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   25-OCT-2017, entry version 53.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=ATP_00193;
OS   Phytoplasma mali (strain AT).
OC   Bacteria; Tenericutes; Mollicutes; Acholeplasmatales;
OC   Acholeplasmataceae; Candidatus Phytoplasma;
OC   16SrX (Apple proliferation group).
OX   NCBI_TaxID=482235;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AT;
RX   PubMed=18582369; DOI=10.1186/1471-2164-9-306;
RA   Kube M., Schneider B., Kuhl H., Dandekar T., Heitmann K.,
RA   Migdoll A.M., Reinhardt R., Seemueller E.;
RT   "The linear chromosome of the plant-pathogenic mycoplasma 'Candidatus
RT   Phytoplasma mali'.";
RL   BMC Genomics 9:306-306(2008).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
DR   EMBL; CU469464; CAP18380.1; -; Genomic_DNA.
DR   SMR; B3R0L6; -.
DR   STRING; 37692.ATP_00193; -.
DR   EnsemblBacteria; CAP18380; CAP18380; ATP_00193.
DR   KEGG; pml:ATP_00193; -.
DR   HOGENOM; HOG000235658; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000002020; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    455       Chromosomal replication initiator protein
FT                                DnaA.
FT                                /FTId=PRO_1000189805.
FT   NP_BIND     143    150       ATP. {ECO:0000255|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   455 AA;  54643 MW;  56D06266476BD2BF CRC64;
     MEKYNYIWEK ILKEISKIYS DEVFNETFKN TKKVYKYENE IIFILAENEF IKNKIYKIYL
     SKINEISKSF FKENLNFKFI TKKEIKEEKI DNTNYNIYNY GNLNKKYNFK NFIIGESNKF
     AFEMSKKISE NKEIKINPLY IFGNVGLGKT HLLHSIGNKI IKNNKDKKVL YVKADEFIED
     FINQLKEEKI ENFKLKYRNI DVLLMDDIQI MSEAKRTQIE FFKLFDYLYL NNKQIVITSD
     KNTSELKNIM SRLISRFEAG LIIDIKKPDF KHRINILNQK MYEFEIKKIK INKEILELIA
     SCFVNNIREM EGALLRLFNY IQTYSNEIDL NIAKEILKPL LKGKMNNFKN KSYKKEYLEK
     INIIISSFYN IEINELLGKK KHKKYTLPRH ISMYLSKKLY KFSYNEIGKF FKKNHSAISK
     GCKKIEKNIE QNTEFKKSVD FIIKKIKSKE ETEEI
//
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