GenomeNet

Database: UniProt
Entry: DNAA_PROAC
LinkDB: DNAA_PROAC
Original site: DNAA_PROAC 
ID   DNAA_PROAC              Reviewed;         500 AA.
AC   Q6ABL5;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   07-JUN-2017, entry version 82.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=PPA0001;
OS   Propionibacterium acnes (strain KPA171202 / DSM 16379).
OC   Bacteria; Actinobacteria; Propionibacteriales; Propionibacteriaceae;
OC   Cutibacterium.
OX   NCBI_TaxID=267747;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KPA171202 / DSM 16379;
RX   PubMed=15286373; DOI=10.1126/science.1100330;
RA   Brueggemann H., Henne A., Hoster F., Liesegang H., Wiezer A.,
RA   Strittmatter A., Hujer S., Duerre P., Gottschalk G.;
RT   "The complete genome sequence of Propionibacterium acnes, a commensal
RT   of human skin.";
RL   Science 305:671-673(2004).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
DR   EMBL; AE017283; AAT81766.1; -; Genomic_DNA.
DR   RefSeq; WP_002515747.1; NC_006085.1.
DR   ProteinModelPortal; Q6ABL5; -.
DR   SMR; Q6ABL5; -.
DR   STRING; 267747.PPA0001; -.
DR   EnsemblBacteria; AAT81766; AAT81766; PPA0001.
DR   GeneID; 2931966; -.
DR   KEGG; pac:PPA0001; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235658; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   Proteomes; UP000000603; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    500       Chromosomal replication initiator protein
FT                                DnaA.
FT                                /FTId=PRO_0000114232.
FT   NP_BIND     203    210       ATP. {ECO:0000255|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   500 AA;  56018 MW;  4656DA79E051F60C CRC64;
     MSDTPFGDAD HPRPAPIHPD AVLPPPMSSQ SADNDPTEAL NEAWTNILTK VSKPNRAWLS
     NTTPVTMHSS TAMVAVPNEF ARDRLESKMR YELEELLSDH FHKAIHLAIT IDPDLELALG
     APDHEDEEEE VPPAQFVPKV TVGVTEPSAR PTTTIDDDEG NRLNPKYTFD SFVIGASNRF
     AHAAAVAVAE APGKSYNPLL IYGGSGLGKT HLLHAIGRYV MSYYDNVKVK YVSTEELTND
     FINAIGTNRT TEFRRSYRDV DVLLVDDIQF LQSKIQTQEE FFHTFNTLHN AQKQIVMTSD
     RPPKLLEALE PRLRSRFEWG LLTDIQPPDL ETRIAILRRK VAAEKITVEP DVLEFIASRI
     QTNIRELEGA LIRVTAFASL NQQPVDISLA EVVLKDLIPE GRETPVTPER IIAETADYFD
     ISADDLLGTS RAQTLVTARQ IAMYLCRELT DLSLPKIGAE FGGKDHTTVM HADRKIRALM
     GEQRQIFNQV SEITNRIKQY
//
DBGET integrated database retrieval system