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Database: UniProt
Entry: DNAA_PSELT
LinkDB: DNAA_PSELT
Original site: DNAA_PSELT 
ID   DNAA_PSELT              Reviewed;         444 AA.
AC   A8F346;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   07-JUN-2017, entry version 65.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=Tlet_0001;
OS   Pseudothermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / NBRC
OS   107922 / TMO) (Thermotoga lettingae).
OC   Bacteria; Thermotogae; Thermotogales; Thermotogaceae;
OC   Pseudothermotoga.
OX   NCBI_TaxID=416591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-301 / DSM 14385 / NBRC 107922 / TMO;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T.,
RA   Dalin E., Tice H., Pitluck S., Foster B., Bruce D., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Nelson K.,
RA   Gogarten J.P., Noll K., Richardson P.;
RT   "Complete sequence of Thermotoga lettingae TMO.";
RL   Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
DR   EMBL; CP000812; ABV32574.1; -; Genomic_DNA.
DR   RefSeq; WP_012002055.1; NC_009828.1.
DR   ProteinModelPortal; A8F346; -.
DR   SMR; A8F346; -.
DR   STRING; 416591.Tlet_0001; -.
DR   EnsemblBacteria; ABV32574; ABV32574; Tlet_0001.
DR   KEGG; tle:Tlet_0001; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235658; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000002016; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    444       Chromosomal replication initiator protein
FT                                DnaA.
FT                                /FTId=PRO_1000060022.
FT   NP_BIND     141    148       ATP. {ECO:0000255|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   444 AA;  51380 MW;  F94973FA21698ED8 CRC64;
     MKSEIIESLK SKLNRRVWES WFGTFDVKEI GPDYVVFQVG NLFIREWLEK KYGSLISKTL
     RELFGKPMDF RIEHASAKTE EKLDSNEDEP LVKKRPLILT PLNPILTFEN FVVGPNNMFA
     YSTCLEVAKN PGKYNPLFLH GGVGLGKTHL LQAIGHYLFK HEPDMRVIYL TSERFLNELV
     DSIKKNRVQE FRDKFRNKID VLLLDDVQFL IGKTGIQTEL FHTFNELYNE GKQIVVCSDR
     DPQQLEKFQD RLVSRFQMGV VTKIEKPDEE TCFKIAQKMA QLENAELQED ILKLISKNFS
     DNLRRLRGAL VKLIMYQQIS GEKVDLQKAF ELLAIQNSYH NKSLPEEKLM NSICEIFGVS
     QEEILSKSRK KEVALARQIG MYVARNYMGF SLRKVADMFK RSHPTVSHTI QKLEELTNSG
     NMVIKSQIDR LARCVTGQIL DQSV
//
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