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Database: UniProt
Entry: DNAA_RALSO
LinkDB: DNAA_RALSO
Original site: DNAA_RALSO 
ID   DNAA_RALSO              Reviewed;         522 AA.
AC   Q8XTV4;
DT   07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   05-JUL-2017, entry version 93.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=RSc3442; ORFNames=RS01823;
OS   Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Ralstonia.
OX   NCBI_TaxID=267608;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GMI1000;
RX   PubMed=11823852; DOI=10.1038/415497a;
RA   Salanoubat M., Genin S., Artiguenave F., Gouzy J., Mangenot S.,
RA   Arlat M., Billault A., Brottier P., Camus J.-C., Cattolico L.,
RA   Chandler M., Choisne N., Claudel-Renard C., Cunnac S., Demange N.,
RA   Gaspin C., Lavie M., Moisan A., Robert C., Saurin W., Schiex T.,
RA   Siguier P., Thebault P., Whalen M., Wincker P., Levy M.,
RA   Weissenbach J., Boucher C.A.;
RT   "Genome sequence of the plant pathogen Ralstonia solanacearum.";
RL   Nature 415:497-502(2002).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
DR   EMBL; AL646052; CAD16939.1; -; Genomic_DNA.
DR   PDB; 1V0G; Model; -; A=1-522.
DR   PDBsum; 1V0G; -.
DR   ProteinModelPortal; Q8XTV4; -.
DR   SMR; Q8XTV4; -.
DR   STRING; 267608.RSc3442; -.
DR   EnsemblBacteria; CAD16939; CAD16939; RSc3442.
DR   KEGG; rso:RSc3442; -.
DR   PATRIC; fig|267608.8.peg.3483; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235659; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000001436; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   3D-structure; ATP-binding; Complete proteome; Cytoplasm;
KW   DNA replication; DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    522       Chromosomal replication initiator protein
FT                                DnaA.
FT                                /FTId=PRO_0000114242.
FT   NP_BIND     227    234       ATP. {ECO:0000255|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   522 AA;  58491 MW;  005BB3DE27C3A58D CRC64;
     MQDFWHAASA QLESELTPQQ FKTWIKPLTP LSFDEQACML RIAAPNRFKL DWVKSQFSGR
     IQSLACDYWE MQVDVQFVLD PTAGQRQAAM QPALAPMPMQ PLAAQTMQAQ AVPREAPARP
     TMAPYRETPM ATAAHAAADI DVPVMDAAEA STQSYRVPAP AAPAVMGGLS APPAAPVDDT
     VHERSRLNPI LTFDNLVTGK ANQLARAAAV QVANNPGKSY NPLYLYGGVG LGKTHLIHAI
     GNFMLMENPR ARIRYIHAEQ YVSDVVKAYQ RKAFDDFKRY YHSLDLLLID DIQFFSGKNR
     TQEEFFYAFE ALIANRAQVI ITSDTYPKEI TGIDDRLISR FDSGLTVAIE PPELEMRVAI
     LMKKAQAENV TVPEEVAFFV AKHLRSNVRE LEGALRKILA YSNFHGKEIT IEVTREALKD
     LLTVQNRQIS VENIQKTCAD FYNIKVADMY SKKRPANIAR PRQIAMYLAK ELTQKSLPEI
     GELFGGRDHT TVLHAVRKIA DERSKDAQLN HELHVLEQTL KG
//
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