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Database: UniProt
Entry: DNAA_RHOE4
LinkDB: DNAA_RHOE4
Original site: DNAA_RHOE4 
ID   DNAA_RHOE4              Reviewed;         520 AA.
AC   C0ZLE1;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-MAY-2009, sequence version 1.
DT   25-OCT-2017, entry version 55.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=RER_00010;
OS   Rhodococcus erythropolis (strain PR4 / NBRC 100887).
OC   Bacteria; Actinobacteria; Corynebacteriales; Nocardiaceae;
OC   Rhodococcus.
OX   NCBI_TaxID=234621;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PR4 / NBRC 100887;
RA   Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S.,
RA   Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.;
RT   "Comparison of the complete genome sequences of Rhodococcus
RT   erythropolis PR4 and Rhodococcus opacus B4.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
DR   EMBL; AP008957; BAH30709.1; -; Genomic_DNA.
DR   RefSeq; WP_003942491.1; NC_012490.1.
DR   ProteinModelPortal; C0ZLE1; -.
DR   SMR; C0ZLE1; -.
DR   STRING; 234621.RER_00010; -.
DR   EnsemblBacteria; BAH30709; BAH30709; RER_00010.
DR   GeneID; 31539874; -.
DR   KEGG; rer:RER_00010; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235658; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000002204; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    520       Chromosomal replication initiator protein
FT                                DnaA.
FT                                /FTId=PRO_1000205660.
FT   NP_BIND     221    228       ATP. {ECO:0000255|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   520 AA;  58241 MW;  82C55421043B5D6B CRC64;
     MNDDPNALAR VWVDVVAELT SDDPGSNLPA LSSKQKAFVR LVRPLTLAQG FALLSVPSPF
     AQETIERDLR EPILQALGRH LGGQVEGLGV RIALEDDADA PAEPVEERTG SRQFESVNSS
     GAYRRRRFTE GDGEPSDSET AETEEVDDDR EALASVHESW PSYFTKPPAT PSASGSGANS
     LNAKYTFDTF VIGSSNRFAH AAAVAIAEAP ARAYNPLFIW GASGLGKTHL LHAAGHYAQR
     LFPGMRVKYV STEEFTNDFI NSLRDDRKVA FKRRYRETDV LLVDDIQFIE GKEGIQEEFF
     HTFNTLHNAN KQIVVSSDRP PKQLATLEER LRTRFEWGLI TDVQPPELET RIAILSKKAR
     MDRLEVPHDV LELIASRIER NIRELEGALI RVTAFASLNR QPLDLTLAEV VLRDLMPDSS
     SLEINAATIM AVTAEYFNMS IDDLCGPGKA RPLAQARQIS MYLCRELTDL SLPKIGQTFG
     RDHTTVMYAD KKIRKEMTER RKVYDQVQEL TARIKQRSKR
//
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