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Database: UniProt
Entry: DNAA_RICPR
LinkDB: DNAA_RICPR
Original site: DNAA_RICPR 
ID   DNAA_RICPR              Reviewed;         463 AA.
AC   Q59758;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-OCT-2017, entry version 98.
DE   RecName: Full=Chromosomal replication initiator protein DnaA;
GN   Name=dnaA; OrderedLocusNames=RP601;
OS   Rickettsia prowazekii (strain Madrid E).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; typhus group.
OX   NCBI_TaxID=272947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Madrid E;
RX   PubMed=9770078;
RA   Waite R.T., Shaw E.I., Winkler H.H., Wood D.O.;
RT   "Isolation and characterization of the dnaA gene of Rickettsia
RT   prowazekii.";
RL   Acta Virol. 42:95-101(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Madrid E;
RX   PubMed=9823893; DOI=10.1038/24094;
RA   Andersson S.G.E., Zomorodipour A., Andersson J.O.,
RA   Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K.,
RA   Eriksson A.-S., Winkler H.H., Kurland C.G.;
RT   "The genome sequence of Rickettsia prowazekii and the origin of
RT   mitochondria.";
RL   Nature 396:133-140(1998).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000305}.
DR   EMBL; U55213; AAA99160.1; -; Genomic_DNA.
DR   EMBL; AJ235272; CAA15045.1; -; Genomic_DNA.
DR   PIR; C71665; C71665.
DR   RefSeq; NP_220969.1; NC_000963.1.
DR   RefSeq; WP_004597944.1; NC_000963.1.
DR   ProteinModelPortal; Q59758; -.
DR   SMR; Q59758; -.
DR   STRING; 272947.RP601; -.
DR   EnsemblBacteria; CAA15045; CAA15045; CAA15045.
DR   GeneID; 883515; -.
DR   KEGG; rpr:RP601; -.
DR   PATRIC; fig|272947.5.peg.619; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235660; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   Proteomes; UP000002480; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    463       Chromosomal replication initiator protein
FT                                DnaA.
FT                                /FTId=PRO_0000114247.
FT   NP_BIND     168    175       ATP. {ECO:0000255}.
SQ   SEQUENCE   463 AA;  53005 MW;  F3CA5683DD3BB1A1 CRC64;
     MSTNQIPLTD QGDNYVNVWS YVAQDLYNHY GETLYNSWFS KVNFIESSLN TVILCAPTNF
     IRDWIKSKYA MVILQLFQHY NNAIKSIEII TKELPGTTQA VIESPTKTFA DIGNSALNSE
     NIVSTLDVRF TFDNFVVGVP NELAYAAARA VAESSGAVFE SNPLFLYGGV GLGKTHLMHA
     IGWYIKQNNP RRKVIYMSAE KFMYQFVKAL RNKEVILFKE KFRSVDVLMI DDIQFICGKD
     STQEEFFHTF NTLIDNNRQM VISCDRSPSD LDNIEDRIKS RLGWGLVADV HSTTYELRLG
     ILESKIEQMN VKIPKDVINF LASKIVSNVR ELEGALNKVI AHSNFTLKAI TLENTQNILR
     DLLRSNERII TVEDIQKKVA SRYNIKLSDM YSSRRLREVA RPRQIAMYLS KTLTPKSLAD
     IGKKFGKKDH TTVMHAIKKV EELLENDIEL REEINLLMKI LQN
//
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