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Database: UniProt
Entry: DNAA_STAA8
LinkDB: DNAA_STAA8
Original site: DNAA_STAA8 
ID   DNAA_STAA8              Reviewed;         453 AA.
AC   Q2G2H5;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-OCT-2017, entry version 84.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=SAOUHSC_00001;
OS   Staphylococcus aureus (strain NCTC 8325).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W.,
RA   Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press,
RL   Washington D.C. (2006).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
DR   EMBL; CP000253; ABD29192.1; -; Genomic_DNA.
DR   RefSeq; WP_001290433.1; NC_007795.1.
DR   RefSeq; YP_498609.1; NC_007795.1.
DR   ProteinModelPortal; Q2G2H5; -.
DR   SMR; Q2G2H5; -.
DR   STRING; 93061.SAOUHSC_00001; -.
DR   EnsemblBacteria; ABD29192; ABD29192; SAOUHSC_00001.
DR   GeneID; 31212825; -.
DR   GeneID; 3919798; -.
DR   KEGG; sao:SAOUHSC_00001; -.
DR   PATRIC; fig|93061.5.peg.1; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235658; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   PRO; PR:Q2G2H5; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IBA:GO_Central.
DR   GO; GO:0006270; P:DNA replication initiation; IBA:GO_Central.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    453       Chromosomal replication initiator protein
FT                                DnaA.
FT                                /FTId=PRO_1000048733.
FT   NP_BIND     156    163       ATP. {ECO:0000255|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   453 AA;  51966 MW;  FD182A5E25F9ABD9 CRC64;
     MSEKEIWEKV LEIAQEKLSA VSYSTFLKDT ELYTIKDGEA IVLSSIPFNA NWLNQQYAEI
     IQAILFDVVG YEVKPHFITT EELANYSNNE TATPKETTKP STETTEDNHV LGREQFNAHN
     TFDTFVIGPG NRFPHAASLA VAEAPAKAYN PLFIYGGVGL GKTHLMHAIG HHVLDNNPDA
     KVIYTSSEKF TNEFIKSIRD NEGEAFRERY RNIDVLLIDD IQFIQNKVQT QEEFFYTFNE
     LHQNNKQIVI SSDRPPKEIA QLEDRLRSRF EWGLIVDITP PDYETRMAIL QKKIEEEKLD
     IPPEALNYIA NQIQSNIREL EGALTRLLAY SQLLGKPITT ELTAEALKDI IQAPKSKKIT
     IQDIQKIVGQ YYNVRIEDFS AKKRTKSIAY PRQIAMYLSR ELTDFSLPKI GEEFGGRDHT
     TVIHAHEKIS KDLKEDPIFK QEVENLEKEI RNV
//
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