ID DNAA_STAA8 Reviewed; 453 AA.
AC Q2G2H5;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 1.
DT 27-MAR-2024, entry version 107.
DE RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN OrderedLocusNames=SAOUHSC_00001;
OS Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=93061;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC 8325 / PS 47;
RA Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT "The Staphylococcus aureus NCTC 8325 genome.";
RL (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL D.C. (2006).
CC -!- FUNCTION: Plays an important role in the initiation and regulation of
CC chromosomal replication. Binds to the origin of replication; it binds
CC specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.
CC {ECO:0000255|HAMAP-Rule:MF_00377}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC Rule:MF_00377}.
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DR EMBL; CP000253; ABD29192.1; -; Genomic_DNA.
DR RefSeq; WP_001290433.1; NZ_LS483365.1.
DR RefSeq; YP_498609.1; NC_007795.1.
DR AlphaFoldDB; Q2G2H5; -.
DR SMR; Q2G2H5; -.
DR STRING; 93061.SAOUHSC_00001; -.
DR PaxDb; 1280-SAXN108_0001; -.
DR GeneID; 3919798; -.
DR KEGG; sao:SAOUHSC_00001; -.
DR PATRIC; fig|93061.5.peg.1; -.
DR eggNOG; COG0593; Bacteria.
DR HOGENOM; CLU_026910_3_1_9; -.
DR OrthoDB; 9807019at2; -.
DR PRO; PR:Q2G2H5; -.
DR Proteomes; UP000008816; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003688; F:DNA replication origin binding; IBA:GO_Central.
DR GO; GO:0006260; P:DNA replication; IBA:GO_Central.
DR GO; GO:0006270; P:DNA replication initiation; IBA:GO_Central.
DR GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR CDD; cd00009; AAA; 1.
DR CDD; cd06571; Bac_DnaA_C; 1.
DR Gene3D; 1.10.1750.10; -; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.30.300.180; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00377; DnaA_bact; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR001957; Chromosome_initiator_DnaA.
DR InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR InterPro; IPR013317; DnaA.
DR InterPro; IPR013159; DnaA_C.
DR InterPro; IPR024633; DnaA_N_dom.
DR InterPro; IPR038454; DnaA_N_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010921; Trp_repressor/repl_initiator.
DR NCBIfam; TIGR00362; DnaA; 1.
DR PANTHER; PTHR30050; CHROMOSOMAL REPLICATION INITIATOR PROTEIN DNAA; 1.
DR PANTHER; PTHR30050:SF2; CHROMOSOMAL REPLICATION INITIATOR PROTEIN DNAA; 1.
DR Pfam; PF00308; Bac_DnaA; 1.
DR Pfam; PF08299; Bac_DnaA_C; 1.
DR Pfam; PF11638; DnaA_N; 1.
DR PRINTS; PR00051; DNAA.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00760; Bac_DnaA_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48295; TrpR-like; 1.
DR PROSITE; PS01008; DNAA; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..453
FT /note="Chromosomal replication initiator protein DnaA"
FT /id="PRO_1000048733"
FT BINDING 156..163
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00377"
SQ SEQUENCE 453 AA; 51966 MW; FD182A5E25F9ABD9 CRC64;
MSEKEIWEKV LEIAQEKLSA VSYSTFLKDT ELYTIKDGEA IVLSSIPFNA NWLNQQYAEI
IQAILFDVVG YEVKPHFITT EELANYSNNE TATPKETTKP STETTEDNHV LGREQFNAHN
TFDTFVIGPG NRFPHAASLA VAEAPAKAYN PLFIYGGVGL GKTHLMHAIG HHVLDNNPDA
KVIYTSSEKF TNEFIKSIRD NEGEAFRERY RNIDVLLIDD IQFIQNKVQT QEEFFYTFNE
LHQNNKQIVI SSDRPPKEIA QLEDRLRSRF EWGLIVDITP PDYETRMAIL QKKIEEEKLD
IPPEALNYIA NQIQSNIREL EGALTRLLAY SQLLGKPITT ELTAEALKDI IQAPKSKKIT
IQDIQKIVGQ YYNVRIEDFS AKKRTKSIAY PRQIAMYLSR ELTDFSLPKI GEEFGGRDHT
TVIHAHEKIS KDLKEDPIFK QEVENLEKEI RNV
//
