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Database: UniProt
Entry: DNAA_STAS1
LinkDB: DNAA_STAS1
Original site: DNAA_STAS1 
ID   DNAA_STAS1              Reviewed;         455 AA.
AC   Q4A180;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   25-OCT-2017, entry version 89.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=SSP0001;
OS   Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 /
OS   DSM 20229).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=342451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15305 / DSM 20229;
RX   PubMed=16135568; DOI=10.1073/pnas.0502950102;
RA   Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K.,
RA   Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S.,
RA   Hattori M., Ohta T.;
RT   "Whole genome sequence of Staphylococcus saprophyticus reveals the
RT   pathogenesis of uncomplicated urinary tract infection.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
DR   EMBL; AP008934; BAE17146.1; -; Genomic_DNA.
DR   RefSeq; WP_002481962.1; NZ_MTGA01000035.1.
DR   ProteinModelPortal; Q4A180; -.
DR   SMR; Q4A180; -.
DR   STRING; 342451.SSP0001; -.
DR   EnsemblBacteria; BAE17146; BAE17146; SSP0001.
DR   GeneID; 3615456; -.
DR   KEGG; ssp:SSP0001; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235658; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000006371; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    455       Chromosomal replication initiator protein
FT                                DnaA.
FT                                /FTId=PRO_1000048736.
FT   NP_BIND     158    165       ATP. {ECO:0000255|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   455 AA;  52210 MW;  6750959952B2677F CRC64;
     MSEQEIWEKV LTLAQEKVSS ASYQTFLKDT KLFKLQNEQA IVVTDDDFVA NWLKMNYAEI
     IKAALYEAIG HEIAPVFYTE EELKSLHTSE QKEENQPEQP AKKYTPGVDE AVIGGEQFNT
     HNTFETFVIG PGNRFPHAAS LAVAEAPAKA YNPLFIYGGV GLGKTHLMHA IGHYVLDNNP
     DAKVIYTSSE KFTNEFIKSI RDNKTERFRE KYRNIDVLLI DDIQFIQNKE QTQEEFFHTF
     NELHQANKQI VISSDRPPKE IAKLEDRLRS RFEWGLIVDI TPPDYETRMA ILQKKIGEEN
     LNIPTEALTY IANQIQSNIR ELEGALTRVL AFSKLQGQPI TTELTAEALK DIIQAPKSKK
     ITIQDIQKIV GQYYSVRIED FSAKKRTKSI AYPRQIAMYL SRELTDFSLP KIGEEFGGRD
     HTTVIHAHEK IVKDIQNDPT FKQEVENLEK EIRNQ
//
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