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Database: UniProt
Entry: DNAA_STRAW
LinkDB: DNAA_STRAW
Original site: DNAA_STRAW 
ID   DNAA_STRAW              Reviewed;         653 AA.
AC   Q82FD8;
DT   07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-OCT-2017, entry version 94.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=SAV_4316;
OS   Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 /
OS   NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=227882;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 /
RC   NRRL 8165 / MA-4680;
RX   PubMed=11572948; DOI=10.1073/pnas.211433198;
RA   Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C.,
RA   Shinose M., Takahashi Y., Horikawa H., Nakazawa H., Osonoe T.,
RA   Kikuchi H., Shiba T., Sakaki Y., Hattori M.;
RT   "Genome sequence of an industrial microorganism Streptomyces
RT   avermitilis: deducing the ability of producing secondary
RT   metabolites.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 /
RC   NRRL 8165 / MA-4680;
RX   PubMed=12692562; DOI=10.1038/nbt820;
RA   Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T.,
RA   Sakaki Y., Hattori M., Omura S.;
RT   "Complete genome sequence and comparative analysis of the industrial
RT   microorganism Streptomyces avermitilis.";
RL   Nat. Biotechnol. 21:526-531(2003).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
DR   EMBL; BA000030; BAC72028.1; -; Genomic_DNA.
DR   RefSeq; WP_010985741.1; NZ_JZJK01000079.1.
DR   ProteinModelPortal; Q82FD8; -.
DR   SMR; Q82FD8; -.
DR   STRING; 227882.SAV_4316; -.
DR   EnsemblBacteria; BAC72028; BAC72028; SAVERM_4316.
DR   KEGG; sma:SAV_4316; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235658; -.
DR   KO; K02313; -.
DR   OMA; FPERDPY; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000000428; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    653       Chromosomal replication initiator protein
FT                                DnaA.
FT                                /FTId=PRO_0000114269.
FT   NP_BIND     354    361       ATP. {ECO:0000255|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   653 AA;  72545 MW;  432A1EBC23C985FB CRC64;
     MADVPADLAA VWPRVLEQLL GEGRGQGVEV KDEHWIKRCQ PLALVADTAL LAVPNEFAKG
     VLEGRLAPIV SETLSRECGR PIRIAITVDD SAGEPPASAS PAPPRYEEPE LPSGPGQGRD
     PYESRGREGY EGYGRHRADD HRQGHNDRHQ GGPGDQLPPS RGDQLPTARP AYPDYQRPEP
     GAWPRPSQDD YGWQQQRLGF PERDPYASPS QDYRPQSMDR PSYDQDRPSY DHDRPSYDHD
     RPSYEQQRAD YDQQRSDYDK RPDRRNIPDS SPGSGHVHRG GPVGSALPAS SGAPGPLAAQ
     PAPATGPGEP TARLNPKYLF DTFVIGASNR FAHAAAVAVA EAPAKAYNPL FIYGESGLGK
     THLLHAIGHY ARSLYPGTRV RYVSSEEFTN EFINSIRDGK GDSFRKRYRE MDILLVDDIQ
     FLADKESTQE EFFHTFNTLH NANKQIVLSS DRPPKQLVTL EDRLRNRFEW GLITDVQPPE
     LETRIAILRK KAVQEQLNAP PEVLEFIASR ISRNIRELEG ALIRVTAFAS LNRQPVDLGL
     TEIVLKDLIP GGEDSAPEIT APAIMAATAD YFGLTVEDLC GTSRGRALVT ARQIAMYLCR
     ELTDLSLPKI GAQFGGRDHT TVMHADRKIR ALMAERRSIY NQVTELTNRI KNG
//
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