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Database: UniProt
Entry: DNAA_STRCO
LinkDB: DNAA_STRCO
Original site: DNAA_STRCO 
ID   DNAA_STRCO              Reviewed;         656 AA.
AC   P27902; Q9KXX4;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   07-JUN-2017, entry version 115.
DE   RecName: Full=Chromosomal replication initiator protein DnaA;
GN   Name=dnaA; OrderedLocusNames=SCO3879; ORFNames=SCH18.16c;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=A3(2) / NRRL B-16638;
RX   PubMed=1577691; DOI=10.1128/jb.174.10.3220-3226.1992;
RA   Calcutt M.J., Schmidt F.J.;
RT   "Conserved gene arrangement in the origin region of the Streptomyces
RT   coelicolor chromosome.";
RL   J. Bacteriol. 174:3220-3226(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H.,
RA   Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M.,
RA   Cronin A., Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S.,
RA   Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S.,
RA   Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S.,
RA   Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K.,
RA   Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J.,
RA   Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces
RT   coelicolor A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000305}.
DR   EMBL; AF187159; AAA26734.1; -; Genomic_DNA.
DR   EMBL; AL939118; CAD55464.1; -; Genomic_DNA.
DR   PIR; A41870; A41870.
DR   RefSeq; NP_733620.1; NC_003888.3.
DR   RefSeq; WP_011029287.1; NC_003888.3.
DR   ProteinModelPortal; P27902; -.
DR   SMR; P27902; -.
DR   STRING; 100226.SCO3879; -.
DR   PRIDE; P27902; -.
DR   EnsemblBacteria; CAD55464; CAD55464; CAD55464.
DR   GeneID; 1099315; -.
DR   KEGG; sco:SCO3879; -.
DR   PATRIC; fig|100226.15.peg.3952; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235658; -.
DR   InParanoid; P27902; -.
DR   KO; K02313; -.
DR   OMA; FPERDPY; -.
DR   OrthoDB; POG091H02FF; -.
DR   PhylomeDB; P27902; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IBA:GO_Central.
DR   GO; GO:0006270; P:DNA replication initiation; IBA:GO_Central.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    656       Chromosomal replication initiator protein
FT                                DnaA.
FT                                /FTId=PRO_0000114271.
FT   NP_BIND     357    364       ATP. {ECO:0000255}.
SQ   SEQUENCE   656 AA;  73183 MW;  6C1D5C0193D3C92B CRC64;
     MADVPADLAA VWPRVLEQLL GEGRGQGVES KDEHWIRRCQ PLALVADTAL LAVPNEFAKG
     VLEGRLAPIV SETLSRECGR PIRIAITVDD TAGEPAGPAP QAPQSPPSRP QHRYEEPELP
     APGQGGREEY RDRDEYEGYG RNRADQLPTA RPAYPQEYQR PEPGSWPRPA QQDDYGWQQQ
     RLGFPERDPY ASPNQEPYGQ EPPPPYSHEN RTSYQQDYRP QPPERPSYDA QRGDYEQARG
     EYEQPRGDYD KPRGDYDQQR GDYDQRGPRR DLPEPPPGSG HVHRGGPVGP GPATGAPGPL
     AAQPAPATGP GEPTARLNPK YLFDTFVIGA SNRFAHAAAV AVAEAPAKAY NPLFIYGESG
     LGKTHLLHAI GHYARSLYPG TRVRYVSSEE FTNEFINSIR DGKGDSFRKR YREMDILLVD
     DIQFLADKES TQEEFFHTFN TLHNANKQIV LSSDRPPKQL VTLEDRLRNR FEWGLITDVQ
     PPELETRIAI LRKKAVQEQL NAPPEVLEFI ASRISRNIRE LEGALIRVTA FASLNRQPVD
     LGLTEIVLKD LIPGGEDSAP EITSTAIMGA TADYFGLTVE DLCGTSRGRA LVTARQIAMY
     LCRELTDLSL PKIGALFGGR DHTTVMHADR KIRNLMAERR SIYNQVTELT NRIKNG
//
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