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Database: UniProt
Entry: DNAA_STRS7
LinkDB: DNAA_STRS7
Original site: DNAA_STRS7 
ID   DNAA_STRS7              Reviewed;         450 AA.
AC   C0MC62;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   30-AUG-2017, entry version 59.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=SZO_00010;
OS   Streptococcus equi subsp. zooepidemicus (strain H70).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=553483;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H70;
RX   PubMed=19325880; DOI=10.1371/journal.ppat.1000346;
RA   Holden M.T.G., Heather Z., Paillot R., Steward K.F., Webb K.,
RA   Ainslie F., Jourdan T., Bason N.C., Holroyd N.E., Mungall K.,
RA   Quail M.A., Sanders M., Simmonds M., Willey D., Brooks K.,
RA   Aanensen D.M., Spratt B.G., Jolley K.A., Maiden M.C.J., Kehoe M.,
RA   Chanter N., Bentley S.D., Robinson C., Maskell D.J., Parkhill J.,
RA   Waller A.S.;
RT   "Genomic evidence for the evolution of Streptococcus equi: host
RT   restriction, increased virulence, and genetic exchange with human
RT   pathogens.";
RL   PLoS Pathog. 5:E1000346-E1000346(2009).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
DR   EMBL; FM204884; CAW97552.1; -; Genomic_DNA.
DR   SMR; C0MC62; -.
DR   STRING; 40041.SZO_00010; -.
DR   EnsemblBacteria; CAW97552; CAW97552; SZO_00010.
DR   KEGG; seq:SZO_00010; -.
DR   HOGENOM; HOG000235658; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000001368; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    450       Chromosomal replication initiator protein
FT                                DnaA.
FT                                /FTId=PRO_1000205663.
FT   NP_BIND     151    158       ATP. {ECO:0000255|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   450 AA;  51480 MW;  40FCDF60817A82AA CRC64;
     MTENEQIFWN RVLELAQSQL KQATYEFFVH DARLIKVDNH VATIFLDQMK ELFWEKNLKD
     VILTAGFEVY NAQIAVDYVY EDNLMIEQQH QGQQGYTEQA FQQLPAVQSD LNPKYSFDNF
     IQGDENRWAV AASIAVANTP GTTYNPLFIW GGPGLGKTHL LNAIGNSVLL ENPNARIKYI
     TAENFINEFV VHIRLDTMDE LKEKFRNLDL LLIDDIQSLA KKTLSGTQEE FFNTFNALHN
     NNKQIVLTSD RTPDHLNDLE DRLVTRFKWG LTVNITPPDF ETRVAILTNK IQEYNFVFPQ
     DTIEYLAGQF DSNVRDLEGA LKDISLVANF KQIDTITVDI AAEAIRARKQ DGPKMTVIPI
     EEIQAQVGKF YGVTVKEIKA TKRTQDIVLA RQVAMFLARE MTDNSLPKIG KEFGGRDHST
     VLHAYNKIKN MIGQDESLRI EIETIKNKIK
//
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