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Database: UniProt
Entry: DNAA_THERP
LinkDB: DNAA_THERP
Original site: DNAA_THERP 
ID   DNAA_THERP              Reviewed;         465 AA.
AC   B9L0U6;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   07-JUN-2017, entry version 52.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=trd_1166;
OS   Thermomicrobium roseum (strain ATCC 27502 / DSM 5159 / P-2).
OC   Bacteria; Chloroflexi; Thermomicrobiales; Thermomicrobiaceae;
OC   Thermomicrobium.
OX   NCBI_TaxID=309801;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27502 / DSM 5159 / P-2;
RX   PubMed=19148287; DOI=10.1371/journal.pone.0004207;
RA   Wu D., Raymond J., Wu M., Chatterji S., Ren Q., Graham J.E.,
RA   Bryant D.A., Robb F., Colman A., Tallon L.J., Badger J.H., Madupu R.,
RA   Ward N.L., Eisen J.A.;
RT   "Complete genome sequence of the aerobic CO-oxidizing thermophile
RT   Thermomicrobium roseum.";
RL   PLoS ONE 4:E4207-E4207(2009).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
DR   EMBL; CP001275; ACM05694.1; -; Genomic_DNA.
DR   RefSeq; WP_015922120.1; NC_011959.1.
DR   ProteinModelPortal; B9L0U6; -.
DR   SMR; B9L0U6; -.
DR   STRING; 309801.trd_1166; -.
DR   EnsemblBacteria; ACM05694; ACM05694; trd_1166.
DR   KEGG; tro:trd_1166; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235658; -.
DR   KO; K02313; -.
DR   OMA; VENWVKD; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000000447; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    465       Chromosomal replication initiator protein
FT                                DnaA.
FT                                /FTId=PRO_1000189817.
FT   NP_BIND     159    166       ATP. {ECO:0000255|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   465 AA;  52221 MW;  26D3F8861FF3FBEB CRC64;
     MRTKQLWQVA LGDLAKRVSR ANFETWLKHT ELVALEGERA TIAAPSSFAA EQLRNKFAAD
     IQETLSLLLG RPIAVHFTVH GQDDEEHPVQ RRPQRRALAS EEGSASKQLS LTPSPEHGLN
     PRYTFEKFVV GPNNRLAHAA ALAVADRPGE KFNPLFIYGG VGLGKTHLLH AIGHRALANR
     PTLKVCYVSS EVFTNELINA IRHQRTDDFR NRYRTIDILM IDDIQFIAGK ESTQEEFFHT
     FNALYQSGKQ IVISSDRPPR LIPDLADRLR SRFEGGLLAD IQPPDLETRQ AILIEKGREL
     GVQMPSDVVE FVARRIESNI RELEGALNRI VALAQLTHQP ITLALAVEAL REGDARAVRE
     QLTPELVLHA VCQHFRVSLA ELVGPGRRRE IVLPRQIAMY LLREELGLSL VEIGQRLGGR
     DHTTVLHGVD KVEEQLRSDE QLRADVLAVR ARLYEDAKAP LASRH
//
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