GenomeNet

Database: UniProt
Entry: DNAA_THICR
LinkDB: DNAA_THICR
Original site: DNAA_THICR 
ID   DNAA_THICR              Reviewed;         467 AA.
AC   Q31JS5;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   07-JUN-2017, entry version 83.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=Tcr_0001;
OS   Thiomicrospira crunogena (strain XCL-2).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Thiotrichales;
OC   Piscirickettsiaceae; Thiomicrospira.
OX   NCBI_TaxID=317025;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=XCL-2;
RX   PubMed=17105352; DOI=10.1371/journal.pbio.0040383;
RA   Scott K.M., Sievert S.M., Abril F.N., Ball L.A., Barrett C.J.,
RA   Blake R.A., Boller A.J., Chain P.S.G., Clark J.A., Davis C.R.,
RA   Detter C., Do K.F., Dobrinski K.P., Faza B.I., Fitzpatrick K.A.,
RA   Freyermuth S.K., Harmer T.L., Hauser L.J., Huegler M., Kerfeld C.A.,
RA   Klotz M.G., Kong W.W., Land M., Lapidus A., Larimer F.W., Longo D.L.,
RA   Lucas S., Malfatti S.A., Massey S.E., Martin D.D., McCuddin Z.,
RA   Meyer F., Moore J.L., Ocampo L.H. Jr., Paul J.H., Paulsen I.T.,
RA   Reep D.K., Ren Q., Ross R.L., Sato P.Y., Thomas P., Tinkham L.E.,
RA   Zeruth G.T.;
RT   "The genome of deep-sea vent chemolithoautotroph Thiomicrospira
RT   crunogena XCL-2.";
RL   PLoS Biol. 4:1-17(2006).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
DR   EMBL; CP000109; ABB40598.1; -; Genomic_DNA.
DR   RefSeq; WP_011369424.1; NC_007520.2.
DR   ProteinModelPortal; Q31JS5; -.
DR   SMR; Q31JS5; -.
DR   STRING; 317025.Tcr_0001; -.
DR   EnsemblBacteria; ABB40598; ABB40598; Tcr_0001.
DR   KEGG; tcx:Tcr_0001; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235659; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000002713; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    467       Chromosomal replication initiator protein
FT                                DnaA.
FT                                /FTId=PRO_1000048754.
FT   NP_BIND     172    179       ATP. {ECO:0000255|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   467 AA;  53058 MW;  9B5E27D0309D33CE CRC64;
     MTTTLWPQVL KQLEAVLNDQ QFLTWIRPLE AVEEDNTLRL IAPSGFILDW VNKKLLSQIK
     QAVYLVAPVN TPEVTLEVGE YAIESFNEPE NTSVPQPLRE TKAEREAAEK AASSTSKKKS
     DSPPKKTIKH NLNTNFTFDT FVEGKANQLA AAAARQVADN PGGSYNPFFI YGGVGLGKTH
     LMHAIGNELM RRDPNARVVY LHSERFVADM VNALRHNKID EFKRFYRSLD ALLIDDIQFF
     AKKEQSQEEF FHTFNTLLEG NKQVILTSDR FPKEVDGLED RLKSRFGWGL TIAVEPPEFE
     MRVAILMKKA AEFGFLLPDE VAFFIAKRLR GNVRDLEGAL KRVGAFAQFT QQLVTVDLAK
     DALKDLLALQ QKMVTLENIQ KTVADYYKIR VADLLSKRRT RNIARPRQMS MAISKELTSH
     SLPEIGDAFG GRDHTTVLHA VRKINELKET DHRIEEDFNS LIRIITN
//
DBGET integrated database retrieval system