UniProt: DRL7

Database: UniProt
Entry: DRL7_ARATH

LinkDB:  DRL7_ARATH 
Original site:  DRL7_ARATH

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Ontology (4)   
   GO (4)   
Gene (3)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
   TAIR (1)   
Protein sequence (2)   
   RefSeq(pep) (2)   
DNA sequence (5)   
   EMBL (5)   
Protein domain (10)   
   InterPro (8)   
   Pfam (2)   
Literature (4)   
   PubMed (4)   
All databases (28)   

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ID   DRL7_ARATH              Reviewed;         907 AA.
AC   Q8W474; F4IBC6; Q9C644; Q9SM05;
DT   11-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   25-JAN-2012, sequence version 4.
DT   27-MAR-2024, entry version 143.
DE   RecName: Full=Probable disease resistance protein At1g58390;
GN   OrderedLocusNames=At1g58390; ORFNames=F9K23.8, X7J.2;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND NUCLEOTIDE SEQUENCE [MRNA] OF 1-592.
RC   STRAIN=cv. Columbia;
RX   PubMed=10548732; DOI=10.1016/s0378-1119(99)00403-5;
RA   Kato A., Suzuki M., Kuwahara A., Ooe H., Higano-Inaba K., Komeda Y.;
RT   "Isolation and analysis of cDNA within a 300 kb Arabidopsis thaliana
RT   genomic region located around the 100 map unit of chromosome 1.";
RL   Gene 239:309-316(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-586.
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
CC   -!- FUNCTION: Possible disease resistance protein.
CC   -!- DOMAIN: The LRR repeats probably act as specificity determinant of
CC       pathogen recognition. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAL32876.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=BAA88265.1; Type=Miscellaneous discrepancy; Note=Cloning artifact.; Evidence={ECO:0000305};
CC   -!- WEB RESOURCE: Name=NIB-LRRS; Note=Functional and comparative genomics
CC       of disease resistance gene homologs;
CC       URL="http://niblrrs.ucdavis.edu";
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DR   EMBL; AB008018; BAA88265.1; ALT_SEQ; mRNA.
DR   EMBL; AB077822; BAB83871.1; -; Genomic_DNA.
DR   EMBL; AC082643; AAG50638.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE33544.1; -; Genomic_DNA.
DR   EMBL; CP002684; ANM60615.1; -; Genomic_DNA.
DR   EMBL; AY062798; AAL32876.1; ALT_INIT; mRNA.
DR   PIR; F96617; F96617.
DR   PIR; T52465; T52465.
DR   RefSeq; NP_001319265.1; NM_001333830.1.
DR   RefSeq; NP_176135.1; NM_104619.3.
DR   AlphaFoldDB; Q8W474; -.
DR   SMR; Q8W474; -.
DR   BioGRID; 27433; 1.
DR   STRING; 3702.Q8W474; -.
DR   iPTMnet; Q8W474; -.
DR   PaxDb; 3702-AT1G58390-1; -.
DR   ProteomicsDB; 224348; -.
DR   EnsemblPlants; AT1G58390.1; AT1G58390.1; AT1G58390.
DR   EnsemblPlants; AT1G58390.2; AT1G58390.2; AT1G58390.
DR   GeneID; 842208; -.
DR   Gramene; AT1G58390.1; AT1G58390.1; AT1G58390.
DR   Gramene; AT1G58390.2; AT1G58390.2; AT1G58390.
DR   KEGG; ath:AT1G58390; -.
DR   Araport; AT1G58390; -.
DR   TAIR; AT1G58390; -.
DR   eggNOG; KOG4658; Eukaryota.
DR   HOGENOM; CLU_000837_25_4_1; -.
DR   InParanoid; Q8W474; -.
DR   OMA; DENYGHI; -.
DR   OrthoDB; 677213at2759; -.
DR   PRO; PR:Q8W474; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q8W474; baseline and differential.
DR   Genevisible; Q8W474; AT.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR   CDD; cd14798; RX-CC_like; 1.
DR   Gene3D; 1.20.5.4130; -; 1.
DR   Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR042197; Apaf_helical.
DR   InterPro; IPR044974; Disease_R_plants.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038005; RX-like_CC.
DR   InterPro; IPR041118; Rx_N.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR   PANTHER; PTHR23155:SF1185; DISEASE RESISTANCE RPP8-LIKE PROTEIN 3-RELATED; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   Pfam; PF18052; Rx_N; 1.
DR   PRINTS; PR00364; DISEASERSIST.
DR   SUPFAM; SSF52058; L domain-like; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Leucine-rich repeat; Nucleotide-binding; Plant defense;
KW   Reference proteome; Repeat.
FT   CHAIN           1..907
FT                   /note="Probable disease resistance protein At1g58390"
FT                   /id="PRO_0000212739"
FT   DOMAIN          144..456
FT                   /note="NB-ARC"
FT   REPEAT          608..631
FT                   /note="LRR 1"
FT   REPEAT          843..868
FT                   /note="LRR 2"
FT   BINDING         190..197
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        587
FT                   /note="R -> K (in Ref. 1; BAA88265)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   907 AA;  104596 MW;  4CA13E4F7A1DF7BA CRC64;
     MAGELVSFGI KKLWDLLSQE CEQFQGVEDQ VTGLKRDLNL LSSFLKDADA KKHTTAVVRN
     VVEEIKEIVY DAEDIIETYL LKEKLWKTSG IKMRIRRHAC IISDRRRNAL DVGGIRTRIS
     DVIRDMQSFG VQQAIVDGGY MQPQGDRQRE MRQTFSKDYE SDFVGLEVNV KKLVGYLVDE
     ENVQVVSITG MGGLGKTTLA RQVFNHEDVK HQFDRLAWVC VSQEFTRKNV WQMILQNLTS
     REKKDEILQM EEAELHDKLF QLLETSKSLI VFDDIWKDED WDLIKPIFPP NKGWKVLLTS
     QNESVAVRGD IKYLNFKPEC LAIEDSWTLF QRIAFPKKDA SESKVDEEME DMGKQMLKHC
     GGLPLAIKVL GGLLAAKYTM HDWERLSVNI GSDIVGRTSS NNSSIYHVLS MSFEELPSYL
     KHCFLYLAHF PEDHKINVEK LSYCWAAEGI STAEDYHNGE TIQDVGQSYL EELVRRNMII
     WERDATASRF GTCHLHDMMR EVCLFKAKEE NFLQIAVKSV GVTSSSTGNS QSPCRSRRLV
     YQCPTTLHVE RDINNPKLRS LVVLWHDLWV ENWKLLGTSF TRLKLLRVLD LFYVDFEGMK
     LPFGIGNLIH LRYLSLQDAK VSHLPSSLGN LMLLIYLNLD VDTEFIFVPD VFMRMHELRY
     LKLPLHMHKK TRLSLRNLVK LETLVYFSTW HSSSKDLCGM TRLMTLAIRL TRVTSTETLS
     ASISGLRNLE YLYIVGTHSK KMREEGIVLD FIHLKHLLLD LYMPRQQHFP SRLTFVKLSE
     CGLEEDPMPI LEKLLHLKGV ILLKGSYCGR RMVCSGGGFP QLKKLEIVGL NKWEEWLVEE
     GSMPLLETLS ILDCEELKEI PDGLRFIYSL ELVMLGTRWK KKFSVGGEDY YKVQHIPSVE
     FIGGYLK
//

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