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Database: UniProt
Entry: E0DHG1_9CORY
LinkDB: E0DHG1_9CORY
Original site: E0DHG1_9CORY 
ID   E0DHG1_9CORY            Unreviewed;       594 AA.
AC   E0DHG1;
DT   02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2010, sequence version 1.
DT   05-JUL-2017, entry version 40.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:EFM48281.1};
GN   ORFNames=HMPREF0299_5113 {ECO:0000313|EMBL:EFM48281.1};
OS   Corynebacterium matruchotii ATCC 14266.
OC   Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC   Corynebacterium.
OX   NCBI_TaxID=553207 {ECO:0000313|EMBL:EFM48281.1, ECO:0000313|Proteomes:UP000004218};
RN   [1] {ECO:0000313|EMBL:EFM48281.1, ECO:0000313|Proteomes:UP000004218}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 14266 {ECO:0000313|EMBL:EFM48281.1,
RC   ECO:0000313|Proteomes:UP000004218};
RA   Harkins D.M., Madupu R., Durkin A.S., Torralba M., Methe B.,
RA   Sutton G.G., Nelson K.E.;
RL   Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EFM48281.1}.
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DR   EMBL; ACSH02000006; EFM48281.1; -; Genomic_DNA.
DR   RefSeq; WP_005520330.1; NZ_ACSH02000006.1.
DR   ProteinModelPortal; E0DHG1; -.
DR   STRING; 553207.HMPREF0299_5113; -.
DR   EnsemblBacteria; EFM48281; EFM48281; HMPREF0299_5113.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000004218; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000004218};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004218}.
FT   DOMAIN      287    415       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      499    567       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     295    302       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   594 AA;  65644 MW;  6290D636360389F1 CRC64;
     MTSSDSNQAS QKTWKSVVKE LINGSEQSDD LHIEPIGPQQ RAYLNLARLI GLLDGVAVLA
     VPSAKAKEYL EGNLYGVICM ALSNKFGREY SLAVTVNPTI GKRRDEPEES EDAEQQMLDI
     ATPTSGGRGS RGATTKTAAR KTPRNSRRGK TAAKPAPTPA AAAPQATTPS VSEPPPAQPP
     SGKSVPRKSA AAAPDASPQL ELDDRDMLTI TATGWTTSHT DQADNPVTPQ PATTARATLR
     SREKPAHNPA QDDSLNPRYT FDTYVVSDSN KLPTSAAIAV AEKPARAYNP LFVWGDSGLG
     KTHLMHAIGN YAQQLDPNLR IKYVSSEQFT NDYINSVRDD RQESFKRRYR NLDILMVDDI
     QFLQGKEGTQ EEFFHTFNAL QQGGKQIVLS SDRPPKQLTT LEDRLRTRFQ SGLIADIYPP
     DLETRIAILM KKAEAEQIVA SRDVLELIAS QFSSSIRELE GAFIRVSAWA SLNNQQINLK
     TAEQALEDLM PEHSVLEVTT DTIMAMTAEF FGFTIAQLSG TSKSRPITHA RQIAMYLCRE
     LTELSLPKVG ERFGRDHTTV MHSERKIRKE LAEKRDTYDE IQKITTMIKN YGRG
//
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