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Database: UniProt
Entry: E0MMC0_9RHOB
LinkDB: E0MMC0_9RHOB
Original site: E0MMC0_9RHOB 
ID   E0MMC0_9RHOB            Unreviewed;       596 AA.
AC   E0MMC0;
DT   02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2010, sequence version 1.
DT   05-JUL-2017, entry version 42.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:EFL89904.1};
GN   ORFNames=R2A130_2516 {ECO:0000313|EMBL:EFL89904.1};
OS   Ahrensia sp. R2A130.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Ahrensia.
OX   NCBI_TaxID=744979 {ECO:0000313|EMBL:EFL89904.1, ECO:0000313|Proteomes:UP000003904};
RN   [1] {ECO:0000313|EMBL:EFL89904.1, ECO:0000313|Proteomes:UP000003904}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=R2A130 {ECO:0000313|EMBL:EFL89904.1,
RC   ECO:0000313|Proteomes:UP000003904};
RA   Suzuki M., Ferriera S., Johnson J., Kravitz S., Beeson K., Sutton G.,
RA   Rogers Y.-H., Friedman R., Frazier M., Venter J.C.;
RL   Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EFL89904.1}.
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DR   EMBL; AEEB01000004; EFL89904.1; -; Genomic_DNA.
DR   STRING; 744979.R2A130_2516; -.
DR   EnsemblBacteria; EFL89904; EFL89904; R2A130_2516.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000003904; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000003904};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000003904}.
FT   DOMAIN      286    417       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      502    571       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     294    301       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   596 AA;  64753 MW;  26C6DCB9A1C6D0F0 CRC64;
     MNYCGQSDPR SDFAECAPDG TNKTSIYLMT TVSNSPASAT TASKVPSPAI VAKTASNVPV
     KARATAKPLS RRAPKASTSM TIAVGPTVGA RDVQKWSRVQ AQLMAKLGPE SFASWFDRCR
     LETISKSQLT ISVPTTFLKS WIRTHYAGIL LTLWQEQSEG ILKVDIVVRS AVRSANAESG
     EAVDQLVNGS APSASDATGA PMVSNGGMGT MPGASTQRNF ATLPGEDVPA FGAGAAGRQA
     AEAGVGFAGS PLDPSFTFAT FVEGASNRVA CAAARSVAEA DGTAARFNPL FLHANVGLGK
     THLLQAIAWG ASARNSGIKI LYLTAEYFMW RFASAIRDQS ALSFKESLRD IDLLLIDDMQ
     FLQGKSIQQE FCHLLNALID SAKQVVVAAD RPPAQLESLD ARVRSRLQGG VALEVGSPDI
     EMRKAMLELR YREARREDPN LAIPSDILDY VATRVASSGR DLEGAFNQLL IQHKFSDKPV
     EIEQIEKMLS HLVQSGEQRR VRVEDIQKVV SRHYNVSKND LLSNRRTRII VRPRQIAMYL
     SKMLTPRSLP EIGRRFGGRD HTTVLHAVRK IEGLLKEETQ LAHEIELLKR LIAESA
//
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