ID E0MZH9_9CORY Unreviewed; 309 AA.
AC E0MZH9;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=4-phosphoerythronate dehydrogenase {ECO:0000313|EMBL:EFM43032.1};
DE EC=1.1.1.290 {ECO:0000313|EMBL:EFM43032.1};
GN Name=pdxB {ECO:0000313|EMBL:EFM43032.1};
GN ORFNames=HMPREF0277_1913 {ECO:0000313|EMBL:EFM43032.1};
OS Corynebacterium accolens ATCC 49726.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
OC Corynebacteriaceae; Corynebacterium.
OX NCBI_TaxID=862512 {ECO:0000313|EMBL:EFM43032.1, ECO:0000313|Proteomes:UP000004599};
RN [1] {ECO:0000313|EMBL:EFM43032.1, ECO:0000313|Proteomes:UP000004599}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49726 {ECO:0000313|EMBL:EFM43032.1,
RC ECO:0000313|Proteomes:UP000004599};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|RuleBase:RU003719}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFM43032.1}.
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DR EMBL; AEED01000128; EFM43032.1; -; Genomic_DNA.
DR RefSeq; WP_005284365.1; NZ_GL397138.1.
DR AlphaFoldDB; E0MZH9; -.
DR HOGENOM; CLU_019796_1_0_11; -.
DR Proteomes; UP000004599; Unassembled WGS sequence.
DR GO; GO:0033711; F:4-phosphoerythronate dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR CDD; cd12159; 2-Hacid_dh_2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43333; 2-HACID_DH_C DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR43333:SF1; 2-HACID_DH_C DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003719}.
FT DOMAIN 26..303
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 98..272
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 309 AA; 33117 MW; B3943876E9FB4182 CRC64;
MKYFMGPETW QPTVDDLSAA GHERVENLED AEVYVNTTPS PRRIPEMPDN IGWVQHCFTG
VNQLIDAGLI TPEGLPWCNS AGAFAKPVAE CALGLLLSQA HQHKAFAQAG TWSVAKELDE
AQEWIYDQQG PKKVAILGAG GIGKQLIALL KPFGVHITAV NRSGRPVEGA DEVVAMDDAA
HVWGEADVIF CILPATAETE GLIDAAKFRA MKPSALFINV GRGSTVVTDD LVDALREGEI
AGAGLEVVDP EPLPDDHPLL SLPNCTMTPH IGATKHVAQY HMGDIFNANA AAWEKGEPMP
TQVDPEAGY
//
