ID E0MZW9_9CORY Unreviewed; 1397 AA.
AC E0MZW9;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 24-JAN-2024, entry version 48.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=HMPREF0277_2053 {ECO:0000313|EMBL:EFM42906.1};
OS Corynebacterium accolens ATCC 49726.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
OC Corynebacteriaceae; Corynebacterium.
OX NCBI_TaxID=862512 {ECO:0000313|EMBL:EFM42906.1, ECO:0000313|Proteomes:UP000004599};
RN [1] {ECO:0000313|EMBL:EFM42906.1, ECO:0000313|Proteomes:UP000004599}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49726 {ECO:0000313|EMBL:EFM42906.1,
RC ECO:0000313|Proteomes:UP000004599};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFM42906.1}.
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DR EMBL; AEED01000134; EFM42906.1; -; Genomic_DNA.
DR HOGENOM; CLU_002151_1_0_11; -.
DR Proteomes; UP000004599; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR CDD; cd18785; SF2_C; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR041635; Type_ISP_LLaBIII_C.
DR PANTHER; PTHR47396:SF1; ATP-DEPENDENT HELICASE IRC3-RELATED; 1.
DR PANTHER; PTHR47396; TYPE I RESTRICTION ENZYME ECOKI R PROTEIN; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR Pfam; PF04851; ResIII; 1.
DR Pfam; PF18135; Type_ISP_C; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000313|EMBL:EFM42906.1};
KW Helicase {ECO:0000313|EMBL:EFM42906.1};
KW Hydrolase {ECO:0000313|EMBL:EFM42906.1};
KW Nucleotide-binding {ECO:0000313|EMBL:EFM42906.1}.
FT DOMAIN 250..348
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|SMART:SM00490"
FT REGION 413..446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 417..443
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1397 AA; 155434 MW; 0CAB77E5DBB859D0 CRC64;
MRAFAVCSDS KVSKKAEDIA VYDLEVPVST EGADIARRFA SGKRAKGLNI VFSTYQSLPA
VHEAQQHGLD DFDLVICDEA HRTTGITLAG EDSSNFVRVH DADYIKASKR LYMTATPRLF
DDAVKGKAAE HSAELTSMDD EGIYGPEFYR LGFGEAVDKG LLTDYKVLVM TVDESVAANA
MAHSEDNQIN LSLASAMIGA WNGLAKRSGE LQGKKGGFDE NAHPMQRAVA FAKDIKTSTQ
IAESFPSLIR THQELLKDKA ALSDVSLTNV DLHVAAQHVD GGINAMERGT KLSWIESPAA
EDEARILTNA RCLSEGVDVP ALDSVIFFNP RNSMVDVVQS VGRVMRKSAG KDYGYIILPV
AVAQDVSPSE ALNDNQRFKV VWQILNALRA HDDRFNAKIN SIALNGANAQ EELPIDVNHV
PGDKEKSDKE KLEDAERTKS PEAFEDSSAM TQQIALFSLE QWQEAIYTKL VDKVGTRTYW
EDWADDVATI AENQITRITA LVENADEDLR QEFDEFVEGL RNNLNDGISA DDAISMLSQH
LITAPVFNAL FENHDFITHN PVAQVMEKMV AALSKANLDT ETESLEKFYE SVRIRASEVT
SASGKQQVIK ELYERFFRKA FKKQAEALGI VYTPVEIVDF ILRAADEVSR KHFGKGLSDE
SVSILDPFAG TSTFMVRLLQ SGLIKPEDLA RKYANELFAT EIMLLAYYVS AVNIETTYNA
LREEAAQRND ELAPEYVPFT NIALADTFQV HEEGDIPDLN IFRENNATIE RQKNAPINVV
IGNPPYSAGQ KSANDLNANQ KYPSLDQRIA DTYAAKSTAT SQRTLYDSYL RAFRWATDRI
GDQGIVAFVS NGGWIDGNTG DGVRLSMAED FTDIYIFNLR GNQRTAGEQS RKEGGKVFGS
GSRSTVAITI GIKDPTKSGF QLHYRDIGDY LTAEEKLDIV ESSSIETIEW QSIEPNKEGD
WLNQRSTEFS TWPVVGEKRV KSVRIFEDFS LGLGTNRDTW VYSFDSEQLG NQAKMLQCSY
NDALSAIPSG VSAKDFLASN AEHTNPRKNK WSSSLVASLQ RRESLKGNGN IVSSLYRPFC
KQHVFYDEDF NHRQFRLKSL FPSRAQQNLG FVCVNPGESI KPATLATNLI PDLHLIASSQ
FFPRFTWIPV KAEDGGLFSE GNVVNHGEAS VYGQIGEVVD GYVRVDNITD EIKQIYRDAL
GDDVSGDDIF HFVYGKLHDP SYRSKYAADL KKMLPHIETP SSRAEFDKFA AAGKELMALH
VDYESVEPWP LDIQVKGDES DRETWRVHKM KWAKRKDPET GKNVNDVTKL IYNKQVTISG
IPAEADQYML GSRSAVAWLI DRYQVKKDKA SGIVNDPNDW ADEVGNPRYI VDLIGKVTRV
AMETVRIVDG VDSDKEG
//
